Nirogacestat has 5 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Anakinra, Grapefruit Products, Mao Inhibitors. Patients taking Nirogacestat should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Major
- 5
Major (5)
- Nirogacestat + Anakinra— Gastric acid reducing agent. Decreases nirogacestat exposure, which may reduce effectiveness of nirogacestat.
- Nirogacestat + Grapefruit Products— Strong CYP3A inhibitor. Increases nirogacestat exposure, which may increase risk of adverse reactions.
- Nirogacestat + Mao Inhibitors— Gastric acid reducing agent. Decreases nirogacestat exposure, which may reduce effectiveness of nirogacestat.
- Nirogacestat + Seville Oranges— Strong CYP3A inhibitor. Increases nirogacestat exposure, which may increase risk of adverse reactions.
- Nirogacestat + Starfruit— Strong CYP3A inhibitor. Increases nirogacestat exposure, which may increase risk of adverse reactions.