Foscarbidopa/Foslevodopa has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Phenelzine, Tranylcypromine, Butyrophenones. Patients taking Foscarbidopa/Foslevodopa should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 2
- Moderate
- 8
Contraindicated (2)
- Foscarbidopa/Foslevodopa + Phenelzine— Nonselective MAO inhibitor use with VYALEV is contraindicated. Discontinue at least two weeks prior to initiating VYALEV…
- Foscarbidopa/Foslevodopa + Tranylcypromine— Nonselective MAO inhibitor use with VYALEV is contraindicated. Discontinue at least two weeks prior to initiating VYALEV…
Moderate (8)
- Foscarbidopa/Foslevodopa + Butyrophenones— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Isoniazid— May reduce the effectiveness of foslevodopa. Monitor patients for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Metoclopramide— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Papaverine— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Phenothiazines— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Rasagiline— Selective MAO-B inhibitor may cause orthostatic hypotension with VYALEV. Monitor patients taking these drugs.
- Foscarbidopa/Foslevodopa + Risperidone— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Foscarbidopa/Foslevodopa + Selegiline— Selective MAO-B inhibitor may cause orthostatic hypotension with VYALEV. Monitor patients taking these drugs.