Rilzabrutinib has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Antacids Containing Calcium, Grapefruit Products, Histamine. Patients taking Rilzabrutinib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Moderate
- 6
Moderate (6)
- Rilzabrutinib + Antacids Containing Calcium— Antacids decrease rilzabrutinib exposure due to pH-dependent solubility. Administer WAYRILZ at least 2 hours before anta…
- Rilzabrutinib + Grapefruit Products— Grapefruit is a moderate CYP3A inhibitor. Concomitant use increases rilzabrutinib exposure and risk of adverse reactions…
- Rilzabrutinib + Histamine— H2 receptor antagonists decrease rilzabrutinib exposure due to pH-dependent solubility. Administer WAYRILZ at least 2 ho…
- Rilzabrutinib + Mao Inhibitors— Proton pump inhibitors decrease rilzabrutinib exposure due to pH-dependent solubility, potentially reducing efficacy. Av…
- Rilzabrutinib + Seville Oranges— Seville oranges are strong CYP3A inhibitors. Concomitant use increases rilzabrutinib exposure and risk of adverse reacti…
- Rilzabrutinib + Starfruit— Starfruit is a moderate CYP3A inhibitor. Concomitant use increases rilzabrutinib exposure and risk of adverse reactions.