Potent CYP3A4 inducer reduces plasma concentrations of caspofungin acetate. Dose increase to 70 mg daily (adults) or 70 mg/m² daily (pediatrics) required.
Source: NLP:caspofungin acetate
Caspofungin Acetate Interactions
Brand names: Caspofungin Acetate
Route: Intravenous
Contraindications
4 CONTRAINDICATIONS Caspofungin is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product [see Adverse Reactions (6)]. • Caspofungin is contraindicated in patients with hypersensitivity to any component of this product.
Pregnancy & Breastfeeding
8.1 Pregnancy Risk Summary Based on animal data, caspofungin may cause fetal harm (see Data). There are insufficient human data to establish whether there is a drug-associated risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes with caspofungin use in pregnant women. In animal studies, caspofungin caused embryofetal toxicity, including increased resorptions, increased peri-implantation loss, and incomplete ossification at multiple fetal sites when administered intravenously to pregnant rats and rabbits during organogenesis at doses up to 0.8 and 2 times the clinical dose, respectively (see Data). Advise patients of the potential risk to the fetus. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Data Animal Data In animal reproduction studies, pregnant rats dosed intravenously with caspofungin during organogenesis (gestational days [GD] 6 to 20) at 0.5, 2, or 5 mg/kg/day (up to 0.8 times the clinical dose based on body surface area comparison) showed increased resorptions and peri-implantation losses at 5 mg/kg/day. Incomplete ossification of the skull and torso and increased incidences of cervical rib were noted in offspring born to pregnant rats treated at doses up to 5 mg/kg/day. In pregnant rabbits treated with intravenous caspofungin during organogenesis (GD 7 to 20) at doses of 1, 3, or 6 mg/kg/day (approximately 2 times the clinical dose based on body surface area comparison), increased fetal resorptions and increased incidence of incomplete ossification of the talus/calcaneus in offspring were observed at the highest dose tested. Caspofungin crossed the placenta in rats and rabbits and was detectable in feta
8 interactions on record
Carbamazepine is a hepatic CYP enzyme inducer expected to reduce caspofungin acetate plasma concentrations. Increased caspofungin dosing should be considered.
Source: NLP:caspofungin acetate
Cyclosporine increases AUC of caspofungin acetate. Transient increases in liver ALT and AST occur with concomitant use. Monitor liver enzymes and evaluate risk/benefit.
Source: NLP:caspofungin acetate
Dexamethasone is a hepatic CYP enzyme inducer expected to reduce caspofungin acetate plasma concentrations. Increased caspofungin dosing should be considered.
Source: NLP:caspofungin acetate
Caspofungin Acetate + EfavirenzModerate
Efavirenz is a hepatic CYP enzyme inducer expected to reduce caspofungin acetate plasma concentrations. Increased caspofungin dosing should be considered.
Source: NLP:caspofungin acetate
Caspofungin Acetate + NevirapineModerate
Nevirapine is a hepatic CYP enzyme inducer expected to reduce caspofungin acetate plasma concentrations. Increased caspofungin dosing should be considered.
Source: NLP:caspofungin acetate
Caspofungin Acetate + PhenytoinModerate
Phenytoin is a hepatic CYP enzyme inducer expected to reduce caspofungin acetate plasma concentrations. Increased caspofungin dosing should be considered.
Source: NLP:caspofungin acetate
Caspofungin Acetate + TacrolimusModerate
Concomitant use with caspofungin acetate requires monitoring. Standard monitoring of tacrolimus trough whole blood concentrations and appropriate dosage adjustments are recommended.
Source: NLP:caspofungin acetate