Home›Meropenem

Meropenem

Also known as: Vabomere

Penem Antibacterial

Route: Intravenous

5 interactions on record

Meropenem has 5 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Divalproex Sodium, Divalproex Sodium Er, Duloxetine D/R. Patients taking Meropenem should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 5

Major (5)

Meropenem + Divalproex Sodium— Co-administration reduces divalproex sodium concentrations below therapeutic range, increasing risk of breakthrough seiz…
Meropenem + Divalproex Sodium Er— Clinically significant reduction in serum valproic acid concentration reported, potentially resulting in loss of seizure…
Meropenem + Duloxetine D/R— Carbapenem antibiotic causing clinically significant reduction in serum valproic acid concentration, potentially resulti…
Meropenem + Probenecid— Probenecid inhibits renal excretion of meropenem, resulting in increased plasma concentrations. Co-administration is not…
Meropenem + Valproic Acid— Co-administration reduces valproic acid concentrations below therapeutic range, increasing risk of breakthrough seizures…

Meropenem + Divalproex Sodium⚠️Major

Co-administration reduces divalproex sodium concentrations below therapeutic range, increasing risk of breakthrough seizures. Use is generally not recommended.

Meropenem + Divalproex Sodium Er⚠️Major

Clinically significant reduction in serum valproic acid concentration reported, potentially resulting in loss of seizure control.

Meropenem + Duloxetine D/R⚠️Major

Carbapenem antibiotic causing clinically significant reduction in serum valproic acid concentration, potentially resulting in loss of seizure control.

Meropenem + Probenecid⚠️Major

Probenecid inhibits renal excretion of meropenem, resulting in increased plasma concentrations. Co-administration is not recommended.

Meropenem + Valproic Acid⚠️Major

Co-administration reduces valproic acid concentrations below therapeutic range, increasing risk of breakthrough seizures. Use is generally not recommended.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.