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Timolol Maleate Ophthalmic Gel Forming Solution 0.25%

Also known as: Timolol Maleate Ophthalmic Gel Forming Solution 0.25%, Timolol Maleate Ophthalmic Gel Forming Solution 0.5%

Route: Ophthalmic

Check Timolol Maleate Ophthalmic Gel Forming Solution 0.25% Interactions →

11 interactions on record

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% has 11 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Beta-Adrenergic Blocking Agents (Topical), Calcium Antagonists, Epinephrine. Patients taking Timolol Maleate Ophthalmic Gel Forming Solution 0.25% should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 11
Major: 5
Moderate: 5

Major (5)

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Beta-Adrenergic Blocking Agents (Topical)— Concomitant use of two topical beta-adrenergic blocking agents is not recommended.
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Calcium Antagonists— Caution advised due to possible atrioventricular conduction disturbances, left ventricular failure, or hypotension. Avoi…
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Epinephrine— Injectable epinephrine interaction noted; see Precautions section regarding anaphylaxis management.
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Quinidine— Potentiated systemic beta-blockade including decreased heart rate and depression has been reported during combined treat…
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Reserpine— Close observation recommended due to possible additive effects and production of hypotension and/or marked bradycardia, …

Moderate (5)

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Clonidine— Oral beta-adrenergic blocking agents may exacerbate rebound hypertension following clonidine withdrawal; no reports with…
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Digitalis Glycosides— Concomitant use may have additive effects in prolonging atrioventricular conduction time.
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Nonselective Beta-Adrenergic Antagonists— Concomitant use of two topical beta-adrenergic blocking agents is not recommended. Patients receiving oral beta-blockers…
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Oral Beta-Adrenergic Blocking Agents— Potential additive effects of beta-blockade, both systemic and on intraocular pressure. Observation for additive effects…
Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Timolol— Drug Interactions Beta-Adrenergic Blocking Agents Patients who are receiving a beta-adrenergic blocking agent orally and…

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Beta-Adrenergic Blocking Agents (Topical)⚠️Major

Concomitant use of two topical beta-adrenergic blocking agents is not recommended.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Calcium Antagonists⚠️Major

Caution advised due to possible atrioventricular conduction disturbances, left ventricular failure, or hypotension. Avoid in patients with impaired cardiac function.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Epinephrine⚠️Major

Injectable epinephrine interaction noted; see Precautions section regarding anaphylaxis management.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Quinidine⚠️Major

Potentiated systemic beta-blockade including decreased heart rate and depression has been reported during combined treatment.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Reserpine⚠️Major

Close observation recommended due to possible additive effects and production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Clonidine🟡Moderate

Oral beta-adrenergic blocking agents may exacerbate rebound hypertension following clonidine withdrawal; no reports with ophthalmic timolol maleate.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Digitalis Glycosides🟡Moderate

Concomitant use may have additive effects in prolonging atrioventricular conduction time.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Nonselective Beta-Adrenergic Antagonists🟡Moderate

Concomitant use of two topical beta-adrenergic blocking agents is not recommended. Patients receiving oral beta-blockers with timolol should be observed for additive effects of beta-blockade.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Oral Beta-Adrenergic Blocking Agents🟡Moderate

Potential additive effects of beta-blockade, both systemic and on intraocular pressure. Observation for additive effects recommended.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Timolol🟡Moderate

Drug Interactions Beta-Adrenergic Blocking Agents Patients who are receiving a beta-adrenergic blocking agent orally and Timolol maleate ophthalmic gel forming solution should be observed for potential additive effects of beta-blockade, both systemic and on intraocular pressure. Calcium Antagonists Caution should be used in the coadministration of beta-adrenergic blocking agents, such as Timolol maleate ophthalmic gel forming solution, and oral or intravenous calcium antagonists because of possible atrioventricular conduction disturbances, left ventricular failure, or hypotension. quinidine, SSRIs) and timolol.

Timolol Maleate Ophthalmic Gel Forming Solution 0.25% + Epinephrine (Injectable)ℹ️Unknown

Interaction noted in precautions regarding anaphylaxis.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.