Ezetimibe has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fenofibrate, Fibrates, Cyclosporine. Patients taking Ezetimibe should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 2
- Major
- 1
- Moderate
- 5
Contraindicated (2)
- Ezetimibe + Fenofibrate— Co-administration of ezetimibe with fibrates other than fenofibrate is not recommended until adequately studied.
- Ezetimibe + Fibrates— Co-administration of ezetimibe with fibrates other than fenofibrate is not recommended until adequately studied.
Major (1)
- Ezetimibe + Cyclosporine— Combination increases exposure of ezetimibe and cyclosporine. Cyclosporine concentrations should be monitored; effect ma…
Moderate (5)
- Ezetimibe + Cholestyramine Light— Cholestyramine decreases mean exposure of total ezetimibe, resulting in reduced efficacy. Administer ezetimibe at least …
- Ezetimibe + Eltrombopag— OATP1B1 substrate; eltrombopag may increase exposure. Monitor closely and consider dose reduction if appropriate.
- Ezetimibe + Eltrombopag Olamine— OATP1B1 substrate; monitor for excessive exposure and consider dose reduction if appropriate.
- Ezetimibe + Gemfibrozil— OATP1B1 substrate; gemfibrozil inhibition may increase ezetimibe exposure, requiring dosing reduction.
- Ezetimibe + Warfarin— If ezetimibe is added to warfarin (a coumarin anticoagulant), the International Normalized Ratio (INR) should be appropr…