Dipyridamole has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Riociguat, Adenosine, Caffeine. Patients taking Dipyridamole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 6
- Moderate
- 2
Contraindicated (1)
- Dipyridamole + Riociguat— Co-administration with dipyridamole is contraindicated because of hypotension.
Major (6)
- Dipyridamole + Adenosine— Dipyridamole increases plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be nece…
- Dipyridamole + Caffeine— Caffeine may abolish the coronary vasodilation induced by intravenous dipyridamole, potentially leading to false negativ…
- Dipyridamole + Cladribine— Potent BCRP, ENT1, and CNT3 transporter inhibitor may alter cladribine bioavailability, intracellular distribution, and …
- Dipyridamole + Enoxaparin Sodium— Platelet inhibitor that may enhance risk of hemorrhage. Discontinue prior to Lovenox initiation if possible, or conduct …
- Dipyridamole + Regadenoson— Dipyridamole increases cardiovascular effects of regadenoson (adenosine A2A-receptor agonist). Risk of cardiovascular si…
- Dipyridamole + Theophylline— Theophylline may abolish the coronary vasodilation induced by intravenous dipyridamole, potentially leading to false neg…
Moderate (2)
- Dipyridamole + Heparin Sodium— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Dipyridamole + Mao Inhibitors— Dipyridamole may counteract anticholinesterase effect of cholinesterase inhibitors, potentially aggravating myasthenia g…