Ethacrynic Acid + FurosemideContraindicated
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
Source: NLP:furosemide
Ethacrynic Acid Interactions
Brand names: Ethacrynic Acid
Loop Diuretic
Route: Oral
Contraindications
CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria. If increasing electrolyte imbalance, azotemia, and/or oliguria occur during treatment of severe, progressive renal disease, the diuretic should be discontinued. In a few patients this diuretic has produced severe, watery diarrhea. If this occurs, it should be discontinued and not used again. Until further experience in infants is accumulated, therapy with oral ethacrynic acid is contraindicated. Hypersensitivity to any component of this product.
Pregnancy & Breastfeeding
Pregnancy Reproduction studies in the mouse and rabbit at doses up to 50 times the human dose showed no evidence of external abnormalities of the fetus due to ethacrynic acid. In a two-litter study in the dog and rat, oral doses of 5 or 20 mg/kg/day (2½ or 10 times the human dose), respectively, did not interfere with pregnancy or with growth and development of the pups. Although there was reduction in the mean body weights of the fetuses in a teratogenic study in the rat at a dose level of 100 mg/kg (50 times the human dose), there was no effect on mortality or postnatal development. Functional and morphologic abnormalities were not observed. There are, however, no adequate and well-controlled studies in pregnant women. Since animal reproduction studies are not always predictive of human response, ethacrynic acid should be used during pregnancy only if clearly needed.
15 interactions on record
Ethacrynic Acid + TobramycinContraindicated
Concomitant administration not recommended due to possible enhancement of aminoglycoside toxicity by altering serum and tissue concentrations.
Source: NLP:tobramycin
Diuretic can enhance aminoglycoside toxicity by altering serum and tissue concentrations. Avoid concomitant use.
Source: NLP:amikacin
Potassium-depleting diuretic causes enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements if necessary.
Source: NLP:fludrocortisone acetate
Risk of ototoxicity when used concomitantly with furosemide. Avoid concomitant use.
Source: NLP:furosemide injection 80 mg/ 10 ml
Concurrent use should be avoided. Diuretic may cause ototoxicity and enhance aminoglycoside toxicity by altering serum and tissue antibiotic concentration.
Source: NLP:gentamicin sulfate
Lithium should not be given with ethacrynic acid as diuretics reduce its renal clearance and add high risk of lithium toxicity.
Source: NLP:ethacrynic acid
Ethacrynic acid may increase the ototoxic potential of aminoglycoside antibiotics; concurrent use should be avoided.
Source: NLP:ethacrynic acid
Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue.
Source: NLP:tobramycin solution
Loop diuretics increase ototoxic potential of this ototoxic drug when used concomitantly with torsemide.
Source: NLP:torsemide
NSAIAs may reduce the diuretic, natriuretic, and antihypertensive effects of ethacrynic acid; patient should be observed closely.
Source: NLP:ethacrynic acid
Ethacrynic Acid + Penicillin GModerate
Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
Source: NLP:penicillin g
Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Source: NLP:penicillin g potassium
Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Source: NLP:penicillin g sodium
Ethacrynic Acid + WarfarinModerate
Ethacrynic acid may displace warfarin from plasma protein binding; reduction in anticoagulant dosage may be required.
Source: NLP:ethacrynic acid