Ethacrynic Acid has 18 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Furosemide, Furosemide, Benzalkonium Chloride, Tobramycin. Patients taking Ethacrynic Acid should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Contraindicated
- 4
- Major
- 9
- Moderate
- 5
Contraindicated (4)
- Ethacrynic Acid + Furosemide— Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
- Ethacrynic Acid + Furosemide, Benzalkonium Chloride— Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
- Ethacrynic Acid + Tobramycin— Concomitant administration not recommended due to possible enhancement of aminoglycoside toxicity by altering serum and …
- Ethacrynic Acid + Tobramycin Inhalation Solution— Should not be administered concomitantly; diuretics can enhance aminoglycoside toxicity by altering antibiotic concentra…
Major (9)
- Ethacrynic Acid + Amikacin— Diuretic can enhance aminoglycoside toxicity by altering serum and tissue concentrations. Avoid concomitant use.
- Ethacrynic Acid + Fludrocortisone Acetate— Potassium-depleting diuretic causes enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements i…
- Ethacrynic Acid + Furosemide Injection 80 Mg/ 10 Ml— Risk of ototoxicity when used concomitantly with furosemide. Avoid concomitant use.
- Ethacrynic Acid + Gentamicin Sulfate— Concurrent use should be avoided. Diuretic may cause ototoxicity and enhance aminoglycoside toxicity by altering serum a…
- Ethacrynic Acid + Lithium— Lithium should not be given with ethacrynic acid as diuretics reduce its renal clearance and add high risk of lithium to…
- Ethacrynic Acid + Macrolide Antibiotics— Ethacrynic acid may increase the ototoxic potential of aminoglycoside antibiotics; concurrent use should be avoided.
- Ethacrynic Acid + Streptomycin— Coadministration potentiates ototoxic effects of streptomycin.
- Ethacrynic Acid + Tobramycin Solution— Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and ti…
- Ethacrynic Acid + Torsemide— Loop diuretics increase ototoxic potential of this ototoxic drug when used concomitantly with torsemide.
Moderate (5)
- Ethacrynic Acid + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIAs may reduce the diuretic, natriuretic, and antihypertensive effects of ethacrynic acid; patient should be observed…
- Ethacrynic Acid + Penicillin G— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Ethacrynic Acid + Penicillin G Potassium— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Ethacrynic Acid + Penicillin G Sodium— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Ethacrynic Acid + Warfarin— Ethacrynic acid may displace warfarin from plasma protein binding; reduction in anticoagulant dosage may be required.