Concomitant use with albuterol tablets may lead to deleterious cardiovascular effects. Combined use not recommended on routine basis.
Source: NLP:albuterol
Albuterol Interactions
Brand names: Albuterol
Route: Oral
Contraindications
CONTRAINDICATIONS Albuterol tablets are contraindicated in patients with a history of hypersensitivity to albuterol, or any of its components.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects Albuterol has been shown to be teratogenic in mice. A study in CD-1 mice at subcutaneous (sc) doses at and above 0.25mg/kg (corresponding to less than the maximum recommended daily oral dose for adults on a mg/m 2 basis), induced cleft palate formation in 5 of 111 (4.5%) fetuses. At an sc dose of 2.5 mg/kg (corresponding to less than the maximum recommended daily oral dose for adults on an mg/m 2 basis) albuterol sulfate induced cleft palate formation in 10 of 108 (9.3%) fetuses. The drug did not induce cleft palate formation when administered at an sc dose, 0.025 mg/kg (significantly less than the maximum recommended daily oral dose for adults on an mg/m 2 basis). Cleft palate also occurred in 22 of 72 (30.5%) fetuses from females treated with 2.5 mg/kg of isoproterenol (positive control) subcutaneously. A reproduction study in Stride Dutch rabbits revealed cranioschisis in 7 of 19 (37%) fetuses when albuterol was administered orally at a dose of 50 mg/kg (approximately 25 times the maximum recommended daily oral dose for adults on an mg/m 2 basis). Studies in pregnant rats with tritiated albuterol demonstrated that approximately 10% of the circulating maternal drug is transferred to the fetus. Disposition in the fetal lungs is comparable to maternal lungs, but fetal liver disposition is 1% of the maternal liver levels. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, albuterol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. During worldwide marketing experience, various congenital anomalies, including cleft palate and limb defects, have been reported in the offspring of patients being treated with albuterol. Some of the mothers were taking multiple medications during their pregnancies. Because no consistent pattern of defects can be discerned, a relationship between albuterol use
21 interactions on record
Beta-blockers block the pulmonary effect of albuterol and may produce severe bronchospasm in asthmatic patients. Patients with asthma should not normally be treated with beta-blockers.
Source: NLP:albuterol
Albuterol + AndthiazideModerate
Non-potassium-sparing thiazide diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especially at higher doses. Caution advised in co-administration.
Source: NLP:albuterol
Albuterol + AtomoxetineModerate
Beta-2 agonist whose cardiovascular action can be potentiated by atomoxetine, resulting in increases in heart rate and blood pressure, particularly with systemic administration.
Source: NLP:atomoxetine
Beta-2 agonist; action on cardiovascular system can be potentiated, resulting in increases in heart rate and blood pressure, particularly with systemic administration.
Source: NLP:atomoxetine hydrochloride
Albuterol + DigoxinModerate
Decreases digoxin concentrations. Requires monitoring and dose adjustment.
Source: NLP:digoxin
Albuterol + GlimepirideModerate
Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Source: NLP:glimepiride
Albuterol + GlipizideModerate
May reduce glucose-lowering effect of glipizide, leading to worsening glycemic control; monitor closely.
Source: NLP:glipizide
Sympathomimetic agent that may decrease the blood glucose lowering effect. Dose adjustment and increased glucose monitoring required.
Source: NLP:insulin aspart
Albuterol + Insulin Aspart-SzjjModerate
May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Source: NLP:insulin aspart-szjj
Albuterol + Insulin DegludecModerate
Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Source: NLP:insulin degludec
Albuterol + Insulin GlargineModerate
May decrease blood glucose lowering effect of insulin glargine; dosage increases and increased glucose monitoring may be required.
Source: NLP:insulin glargine
Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Source: NLP:insulin glargine-aglr
Albuterol + Insulin GlulisineModerate
Sympathomimetic agent may decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Source: NLP:insulin glulisine
Albuterol + Insulin HumanModerate
Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and glucose monitoring may be required.
Source: NLP:insulin human
Albuterol + Insulin Icodec-AbaeModerate
May decrease blood glucose lowering effect of Awiqli. Dose increases and increased glucose monitoring may be required.
Source: NLP:insulin icodec-abae
Albuterol + Insulin LisproModerate
Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Source: NLP:insulin lispro
Albuterol + Insulin Lispro-AabcModerate
Sympathomimetic agent that may decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.
Source: NLP:insulin lispro-aabc
Albuterol + Loop DiureticsModerate
Non-potassium-sparing loop diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especially at higher doses. Caution advised in co-administration.
Source: NLP:albuterol
Beta-agonist; may require increased dosages when used concomitantly with sotalol.
Source: NLP:sotalol hydrochloride
Ipratropium bromide HFA inhalation aerosol has been used concomitantly with albuterol; formal study evaluated interaction effects with respect to safety and effectiveness.
Source: NLP:ipratropium bromide inhalation