High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
Source: NLP:cefpodoxime proxetil
Cefpodoxime Proxetil Interactions
Brand names: Cefpodoxime Proxetil
Route: Oral
Contraindications
CONTRAINDICATIONS Cefpodoxime proxetil is contraindicated in patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics.
Pregnancy & Breastfeeding
PREGNANCY Teratogenic Effects Pregnancy Category B Cefpodoxime proxetil was neither teratogenic nor embryocidal when administered to rats during organogenesis at doses up to 100 mg/kg/day (2 times the human dose based on mg/m 2 ) or to rabbits at doses up to 30 mg/kg/day (1 to 2 times the human dose based on mg/m 2 ). There are, however, no adequate and well-controlled studies of cefpodoxime proxetil use in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
5 interactions on record
Reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
Source: NLP:cefpodoxime proxetil
Inhibits renal excretion resulting in approximately 31% increase in AUC and 20% increase in peak plasma levels.
Source: NLP:cefpodoxime proxetil
Delays peak plasma levels with 47% increase in Tmax, but does not affect extent of absorption.
Source: NLP:cefpodoxime proxetil
High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
Source: NLP:cefpodoxime proxetil