Cefpodoxime Proxetil has 5 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Aluminum Hydroxide, H2 Blockers, Probenecid. Patients taking Cefpodoxime Proxetil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Moderate
- 5
Moderate (5)
- Cefpodoxime Proxetil + Aluminum Hydroxide— High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
- Cefpodoxime Proxetil + H2 Blockers— Reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
- Cefpodoxime Proxetil + Probenecid— Inhibits renal excretion resulting in approximately 31% increase in AUC and 20% increase in peak plasma levels.
- Cefpodoxime Proxetil + Propantheline— Delays peak plasma levels with 47% increase in Tmax, but does not affect extent of absorption.
- Cefpodoxime Proxetil + Sodium Bicarbonate— High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.