Glucagon has 20 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Indomethacin, Insulin Glargine, Glimepiride. Patients taking Glucagon should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Major
- 2
- Moderate
- 18
Major (2)
- Glucagon + Indomethacin— Glucagon may lose its ability to raise blood glucose or may produce hypoglycemia in patients taking indomethacin. Monito…
- Glucagon + Insulin Glargine— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
Moderate (18)
- Glucagon + Glimepiride— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
- Glucagon + Glipizide— May reduce the glucose-lowering effect of glipizide, leading to worsening glycemic control. Monitor closely.
- Glucagon + Insulin Aspart Injection— May decrease the blood glucose lowering effect. Dose adjustment and increased glucose monitoring required.
- Glucagon + Insulin Aspart-Szjj— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
- Glucagon + Insulin Degludec— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Glucagon + Insulin Degludec And Liraglutide— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
- Glucagon + Insulin Detemir— May decrease blood glucose lowering effect of insulin detemir. Dosage increases and increased glucose monitoring may be …
- Glucagon + Insulin Glargine And Lixisenatide— May decrease the blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.
- Glucagon + Insulin Glargine-Aglr— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Glucagon + Insulin Glargine-Yfgn— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Glucagon + Insulin Glulisine— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
- Glucagon + Insulin Human— Insulin acts antagonistically to glucagon. Monitor blood glucose when glucagon is used as a diagnostic aid in patients r…
- Glucagon + Insulin Icodec-Abae— May decrease blood glucose lowering effect of Awiqli. Dose increases and increased glucose monitoring may be required.
- Glucagon + Insulin Lispro— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
- Glucagon + Insulin Lispro-Aabc— May decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.
- Glucagon + Nonselective Beta-Adrenergic Antagonists— Patients taking beta-blockers may have a transient increase in pulse and blood pressure when given glucagon. The increas…
- Glucagon + Repaglinide— May decrease blood glucose lowering effect of repaglinide. Dose increases and increased glucose monitoring may be requir…
- Glucagon + Warfarin— Glucagon may increase the anticoagulant effect of warfarin. Monitor patients for unusual bruising or bleeding; warfarin …