Histamine has 9 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Antihistamines, Cefuroxime Axetil, Doxepin. Patients taking Histamine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Moderate
- 9
Moderate (9)
- Histamine + Antihistamines— Lessen the skin test wheal and erythema responses elicited by histamine. Should be discontinued at least 5 days before s…
- Histamine + Cefuroxime Axetil— Reduce gastric acidity and should be avoided as they may lower bioavailability of cefuroxime axetil.
- Histamine + Doxepin— Tricyclic antidepressant that lessens histamine skin test responses. Should be withheld for at least 7 days before skin …
- Histamine + Gefitinib— Elevates gastric pH and may reduce gefitinib plasma concentrations. Separate gefitinib dosing by 6 hours before or after…
- Histamine + Long Acting Antihistamines— Lessen the skin test wheal and erythema responses elicited by histamine. Should be discontinued for at least 3 weeks pri…
- Histamine + Pitolisant Hydrochloride— Centrally acting H1 receptor antagonists may reduce WAKIX effectiveness. Avoid centrally acting H1 receptor antagonists.
- Histamine + Rilzabrutinib— H2 receptor antagonists decrease rilzabrutinib exposure due to pH-dependent solubility. Administer WAYRILZ at least 2 ho…
- Histamine + Topical Local Anesthetics— May suppress the flare responses to histamine and should be avoided at skin test sites.
- Histamine + Topical Steroids— Lessen the skin test wheal and erythema responses elicited by histamine at the skin test site. Should be discontinued fo…