Histamine + AntihistaminesModerate
Lessen the skin test wheal and erythema responses elicited by histamine. Should be discontinued at least 5 days before skin testing.
Source: NLP:histamine
Histamine Interactions
Brand names: Positive Skin Test Control - Histamine
Route: Percutaneous
FDA Black Box Warning
POSITIVE SKIN TEST CONTROL - HISTAMINE For Percutaneous (Scratch, Prick or Puncture) Administration Histamine Base: 6mg/mL (Histamine Dihydrochloride: 10mg/mL) This product is to be used by a physician or under the supervision of a physician.
Contraindications
CONTRAINDICATIONS Positive Skin Test Control - Histamine is contraindicated in patients with a history of hypersensitivity to histamine products, and in patients with hypotension, severe hypertension, vasomotor instability, severe cardiac, pulmonary or renal disease.
Pregnancy & Breastfeeding
(4) Pregnancy: Positive Skin Test Control-Histamine. Animal reproduction studies have not been conducted on Histamine Dihydrochloride. It is also not known whether Histamine Dihydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Histamine Dihydrochloride should be given to a pregnant woman only if clearly needed.
8 interactions on record
Histamine + Cefuroxime AxetilModerate
Reduce gastric acidity and should be avoided as they may lower bioavailability of cefuroxime axetil.
Source: NLP:cefuroxime axetil
Histamine + DoxepinModerate
Tricyclic antidepressant that lessens histamine skin test responses. Should be withheld for at least 7 days before skin testing.
Source: NLP:histamine
Histamine + GefitinibModerate
Elevates gastric pH and may reduce gefitinib plasma concentrations. Separate gefitinib dosing by 6 hours before or after administration.
Source: NLP:gefitinib
Lessen the skin test wheal and erythema responses elicited by histamine. Should be discontinued for at least 3 weeks prior to skin testing.
Source: NLP:histamine
Histamine + RilzabrutinibModerate
H2 receptor antagonists decrease rilzabrutinib exposure due to pH-dependent solubility. Administer WAYRILZ at least 2 hours before these agents.
Source: NLP:rilzabrutinib
May suppress the flare responses to histamine and should be avoided at skin test sites.
Source: NLP:histamine
Histamine + Topical SteroidsModerate
Lessen the skin test wheal and erythema responses elicited by histamine at the skin test site. Should be discontinued for at least 2-3 weeks before skin testing.
Source: NLP:histamine