Sodium Polystyrene Sulfonate has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Magnesium Hydroxide, Sorbitol, Aluminum Carbonate. Patients taking Sodium Polystyrene Sulfonate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 2
- Major
- 3
- Moderate
- 5
Contraindicated (2)
- Sodium Polystyrene Sulfonate + Magnesium Hydroxide— Should not be administered with sodium polystyrene sulfonate. Risk of systemic alkalosis and seizures reported.
- Sodium Polystyrene Sulfonate + Sorbitol— Concomitant use with sodium polystyrene sulfonate has been implicated in cases of intestinal necrosis, which may be fata…
Major (3)
- Sodium Polystyrene Sulfonate + Aluminum Carbonate— Concomitant use with sodium polystyrene sulfonate may cause systemic alkalosis and reduce potassium exchange capability.
- Sodium Polystyrene Sulfonate + Aluminum Hydroxide— Intestinal obstruction due to concretions has been reported when used in combination with sodium polystyrene sulfonate.
- Sodium Polystyrene Sulfonate + Digitalis Glycosides— Hypokalemia from sodium polystyrene sulfonate may exaggerate digitalis toxicity, including ventricular arrhythmias and A…
Moderate (5)
- Sodium Polystyrene Sulfonate + Cation-Donating Antacids— Simultaneous administration may reduce the resin's potassium exchange capability and increase risk of systemic alkalosis…
- Sodium Polystyrene Sulfonate + Levothyroxine— Sodium Polystyrene Sulfonate may bind thyroxine and decrease its gastrointestinal absorption. Administer at least 3 hour…
- Sodium Polystyrene Sulfonate + Lithium— Sodium Polystyrene Sulfonate may bind lithium and decrease its gastrointestinal absorption. Administer at least 3 hours …
- Sodium Polystyrene Sulfonate + Tenapanor— Separate administration by at least 3 hours. SPS binds to many commonly prescribed oral medicines, potentially reducing …
- Sodium Polystyrene Sulfonate + Triamterene And Hydrochlorothiazide— Exchange resins reduce serum potassium levels by sodium replacement of potassium; fluid retention may occur.