Isoflurane has 26 known drug interactions based on U.S. FDA drug labeling data. 16 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adrenaline, Calcium Antagonists, Dexmedetomidine. Patients taking Isoflurane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 26
- Major
- 16
- Moderate
- 10
Major (16)
- Isoflurane + Adrenaline— Isoflurane sensitizes the myocardium to arrhythmogenic effects of adrenaline. Doses greater than 5 mcg/kg administered s…
- Isoflurane + Calcium Antagonists— Isoflurane may lead to marked hypotension in patients treated with calcium antagonists.
- Isoflurane + Dexmedetomidine— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or isoflurane may be requ…
- Isoflurane + Dexmedetomidine Hydrochloride— Enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or isoflurane may be required. No pharmac…
- Isoflurane + Dexmethylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Isoflurane + Dopamine Hydrochloride— Concomitant use may increase cardiac autonomic irritability and sensitize the myocardium to dopamine, potentially leadin…
- Isoflurane + Fentanyl— Fentanyl decreases MAC of isoflurane and may cause synergistic fall in blood pressure and respiratory rate when combined…
- Isoflurane + Mao Inhibitors— MAO inhibitors combined with isoflurane may increase risk of hemodynamic instability during surgery or medical procedure…
- Isoflurane + Methylphenidate Hydrochloride— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of s…
- Isoflurane + Methylphenidate Hydrochloride Extended Release— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Isoflurane + Nonselective Beta-Adrenergic Antagonists— Concomitant use may exaggerate cardiovascular effects of isoflurane, including hypotension and negative inotropic effect…
- Isoflurane + Norepinephrine Bitartrate— Concomitant use may lead to ventricular tachycardia or ventricular fibrillation. Monitor cardiac rhythm.
- Isoflurane + Propofol— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Isoflurane + Rocuronium Bromide— Enhances neuromuscular blocking activity and prolongs duration of rocuronium bromide action by 11-50% and decreases infu…
- Isoflurane + Succinylcholine Chloride— May enhance the neuromuscular blocking action of succinylcholine.
- Isoflurane + Vecuronium Bromide— Isoflurane enhances vecuronium-induced neuromuscular blockade. Potentiation is most prominent with isoflurane use.
Moderate (10)
- Isoflurane + Atracurium— Isoflurane potentiates the muscle relaxant effect of atracurium, reducing required ED95 by approximately 25-40%. Dose ad…
- Isoflurane + Atracurium Besylate— May enhance the neuromuscular blocking action of atracurium.
- Isoflurane + Dexmedetomidine Hydrochloride In 0.9% Sodium Chloride— Co-administration leads to enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or isoflurane …
- Isoflurane + Muscle Relaxants— Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants…
- Isoflurane + Nitrous Oxide— Nitrous oxide decreases the minimum alveolar concentration (MAC) of isoflurane. Dose adjustment required.
- Isoflurane + Pancuronium— Isoflurane potentiates the muscle relaxant effect of pancuronium, reducing required ED95 by approximately 25-40%. Dose a…
- Isoflurane + Propofol Injectable Emulsion— Concurrent administration during maintenance can increase anesthetic/sedative and cardiorespiratory effects of propofol.
- Isoflurane + Rocuronium— Isoflurane enhances rocuronium activity, prolonging neuromuscular block duration and decreasing infusion requirements by…
- Isoflurane + Succinylcholine— Isoflurane potentiates the muscle relaxant effect of succinylcholine, reducing required ED95 by approximately 25-40%. Do…
- Isoflurane + Vecuronium— Isoflurane potentiates the muscle relaxant effect of vecuronium, reducing required ED95 by approximately 25-40%. Dose ad…