Pralatrexate has 3 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sepiapterin, Nonsteroidal Anti-Inflammatory Drugs (Nsaids), Probenecid. Patients taking Pralatrexate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 3
- Contraindicated
- 1
- Major
- 2
Contraindicated (1)
- Pralatrexate + Sepiapterin— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
Major (2)
- Pralatrexate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Coadministration may increase risk of adverse reactions. Avoid coadministration; if unavoidable, monitor for increased r…
- Pralatrexate + Probenecid— Coadministration increases pralatrexate plasma concentrations, increasing risk of adverse reactions. Avoid coadministrat…