Meclizine has 4 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Scolopamine Transdermal System, Scopolamine, Alcohol. Patients taking Meclizine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 2
- Moderate
- 2
Major (2)
- Meclizine + Scolopamine Transdermal System— Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, and disorientation.
- Meclizine + Scopolamine— Concurrent use may potentiate CNS adverse reactions and increase risk of intestinal obstruction and urinary retention. M…
Moderate (2)
- Meclizine + Alcohol— Coadministration may result in increased CNS depression when used concurrently with meclizine.
- Meclizine + Mao Inhibitors— Potential for drug-drug interactions as meclizine is metabolized by CYP2D6; monitor for adverse reactions and clinical e…