Home›Memantine

Memantine

Also known as: Memantine Hydrochloride

Route: Oral

6 interactions on record

Memantine has 6 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sulfamethoxazole And Trimethoprim, Amantadine, Dextromethorphan. Patients taking Memantine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Major: 1
Moderate: 5

Major (1)

Memantine + Sulfamethoxazole And Trimethoprim— Cases of interactions with memantine have been reported in the literature.

Moderate (5)

Memantine + Amantadine— Combined use of memantine with amantadine has not been systematically evaluated and should be approached with caution du…
Memantine + Dextromethorphan— Combined use of memantine with dextromethorphan has not been systematically evaluated and should be approached with caut…
Memantine + Ketamine— Combined use of memantine with ketamine has not been systematically evaluated and should be approached with caution due …
Memantine + Mao Inhibitors— Carbonic anhydrase inhibitors alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and …
Memantine + Sodium Bicarbonate— Sodium bicarbonate alters urine pH towards alkaline conditions, reducing memantine clearance by about 80% and potentiall…

Memantine + Sulfamethoxazole And Trimethoprim⚠️Major

Cases of interactions with memantine have been reported in the literature.

Memantine + Amantadine🟡Moderate

Combined use of memantine with amantadine has not been systematically evaluated and should be approached with caution due to both being NMDA antagonists.

Memantine + Dextromethorphan🟡Moderate

Combined use of memantine with dextromethorphan has not been systematically evaluated and should be approached with caution due to both being NMDA antagonists.

Memantine + Ketamine🟡Moderate

Combined use of memantine with ketamine has not been systematically evaluated and should be approached with caution due to both being NMDA antagonists.

Memantine + Mao Inhibitors🟡Moderate

Carbonic anhydrase inhibitors alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and potentially leading to drug accumulation and increased adverse effects.

Memantine + Sodium Bicarbonate🟡Moderate

Sodium bicarbonate alters urine pH towards alkaline conditions, reducing memantine clearance by about 80% and potentially leading to drug accumulation and increased adverse effects.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.