Methylene Blue has 51 known drug interactions based on U.S. FDA drug labeling data. Of these, 38 are contraindicated combinations that should be avoided entirely. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atomoxetine Hydrochloride, Atropa Belladonna And Opium, Buspirone. Patients taking Methylene Blue should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 51
- Contraindicated
- 38
- Major
- 12
- Moderate
- 1
Contraindicated (38)
- Methylene Blue + Atomoxetine Hydrochloride— Concomitant use contraindicated. Serious, sometimes fatal reactions including hyperthermia, rigidity, myoclonus, and aut…
- Methylene Blue + Atropa Belladonna And Opium— Intravenous methylene blue MAOI-like interaction may manifest as serotonin syndrome or opioid toxicity.
- Methylene Blue + Buspirone— Intravenous reversible MAOI that increases risk of serotonin syndrome when started with buspirone.
- Methylene Blue + Buspirone Hydrochloride— Intravenous methylene blue (reversible MAOI); starting buspirone is contraindicated due to increased risk of serotonin s…
- Methylene Blue + Citalopram— Concomitant use increases risk of serotonin syndrome. Citalopram is contraindicated in patients taking intravenous methy…
- Methylene Blue + Citalopram Hydrobromide— Concomitant use increases risk of serotonin syndrome. Citalopram is contraindicated in patients taking intravenous methy…
- Methylene Blue + Desvenlafaxine— Intravenous methylene blue is contraindicated due to risk of serotonin syndrome.
- Methylene Blue + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Contraindicated with intravenous methylene blue.
- Methylene Blue + Desvenlafaxine Succinate— Concomitant intravenous methylene blue is contraindicated due to increased risk of serotonin syndrome.
- Methylene Blue + Dexmethylphenidate Hydrochloride— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylene Blue + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Methylene Blue + Doxepin Hydrochloride— Intravenous methylene blue is an MAOI. Concomitant use with doxepin hydrochloride increases risk of serotonin syndrome. …
- Methylene Blue + Duloxetine— Intravenous methylene blue with duloxetine increases risk of serotonin syndrome and is contraindicated.
- Methylene Blue + Escitalopram— MAOI with potential to increase serotonin syndrome risk. Escitalopram is contraindicated in patients taking intravenous …
- Methylene Blue + Escitalopram Oxalate— Concomitant use increases risk of serotonin syndrome. Escitalopram oxalate is contraindicated in patients taking intrave…
- Methylene Blue + Gepirone— Concomitant use increases risk of serotonin syndrome. GEPIRONE is contraindicated in patients taking intravenous methyle…
- Methylene Blue + Hydromorphone Hydrochloride— Not recommended for patients taking MAOIs or within 14 days of stopping. May manifest as serotonin syndrome or opioid to…
- Methylene Blue + Levomilnacipran Hydrochloride— MAOI-like compound that increases risk of serotonin syndrome when used intravenously with levomilnacipran. Contraindicat…
- Methylene Blue + Methylphenidate Hydrochloride— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, an…
- Methylene Blue + Methylphenidate Hydrochloride Extended Release— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylene Blue + Milnacipran Hydrochloride— Do not initiate SAVELLA in patients being treated with intravenous methylene blue. Discontinue SAVELLA before initiating…
- Methylene Blue + Mirtazapine— Intravenous methylene blue increases risk of serotonin syndrome. Mirtazapine is contraindicated in patients taking this …
- Methylene Blue + Morphine Sulfate— Do not use morphine sulfate with intravenous methylene blue. MAOI interaction may manifest as serotonin syndrome or opio…
- Methylene Blue + Oxymorphone Hydrochloride— MAOI-like interaction may result in serotonin syndrome or opioid toxicity.
- Methylene Blue + Paroxetine— Intravenous methylene blue with paroxetine increases risk of serotonin syndrome. Paroxetine is contraindicated in patien…
- Methylene Blue + Paroxetine Hydrochloride— Concomitant use of SSRIs including paroxetine and MAOIs increases the risk of serotonin syndrome.
- Methylene Blue + Paroxetine Hydrochloride Hemihydrate— Concomitant use is contraindicated due to MAOI properties and risk of serotonin syndrome.
- Methylene Blue + Sertraline— Concomitant use increases risk of serotonin syndrome. Sertraline is contraindicated in patients taking intravenous methy…
- Methylene Blue + Sertraline Hydrochloride— Concomitant use of intravenous methylene blue with sertraline hydrochloride increases risk of serotonin syndrome.
- Methylene Blue + Tapentadol Hydrochloride— MAOI activity may cause serotonin syndrome or opioid toxicity when given intravenously.
- Methylene Blue + Tranylcypromine— Intravenous methylene blue is contraindicated; emergency use only with close monitoring and immediate discontinuation of…
- Methylene Blue + Tranylcypromine Sulfate— Intravenous methylene blue is contraindicated. If emergency treatment necessary, discontinue tranylcypromine immediately…
- Methylene Blue + Trazodone Hydrochloride— Intravenous methylene blue concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated.
- Methylene Blue + Venlafaxine— Concomitant use with intravenous methylene blue (an MAOI) increases the risk of serotonin syndrome and is contraindicate…
- Methylene Blue + Venlafaxine Hcl Er— MAOI with properties that increase risk of serotonin syndrome when used with venlafaxine. Contraindicated.
- Methylene Blue + Venlafaxine Hydrochloride— Concomitant use with intravenous methylene blue (MAOI) increases risk of serotonin syndrome. Contraindicated in patients…
- Methylene Blue + Vilazodone Hydrochloride— Intravenous MAOI that increases risk of serotonin syndrome when combined with vilazodone hydrochloride.
- Methylene Blue + Vortioxetine— Concomitant intravenous use increases risk of serotonin syndrome. Contraindicated with IV methylene blue or within 21 da…
Major (12)
- Methylene Blue + Bupropion— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
- Methylene Blue + Clomipramine— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
- Methylene Blue + Dextromethorphan— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
- Methylene Blue + Hydrocodone Bitartrate And Acetaminophen— MAO inhibitor activity may result in serotonin syndrome; carefully observe patient during treatment initiation and dose …
- Methylene Blue + Levorphanol Tartrate— Concomitant use has resulted in serotonin syndrome.
- Methylene Blue + Linezolid— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
- Methylene Blue + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Methylene Blue + Monoamine Oxidase Inhibitors (Maois)— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
- Methylene Blue + Nalbuphine Hydrochloride— MAOI-like interaction may manifest as serotonin syndrome.
- Methylene Blue + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjus…
- Methylene Blue + Remifentanil Hydrochloride— MAOI activity may result in serotonin syndrome or opioid toxicity.
- Methylene Blue + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
Moderate (1)
- Methylene Blue + Butorphanol Tartrate— MAO inhibitor activity may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.