Mitotane has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Doravirine, Doravirine, Lamivudine, And Tenofovir Disoproxil Fumarate, Oral Contraceptives. Patients taking Mitotane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 6
- Major
- 5
- Moderate
- 2
Contraindicated (6)
- Mitotane + Doravirine— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Mitotane + Doravirine, Lamivudine, And Tenofovir Disoproxil Fumarate— Co-administration decreases doravirine plasma concentrations and is contraindicated. At least a 4-week cessation period …
- Mitotane + Oral Contraceptives— Mitotane decreases the levels and efficacy of hormonal contraceptives. Avoid concomitant use.
- Mitotane + Spironolactone— Avoid concomitant use of spironolactone and mitotane.
- Mitotane + Spironolactone And Hydrochlorothiazide— Avoid concomitant use; spironolactone reduces mitotane plasma levels.
- Mitotane + Warfarin— Mitotane induces warfarin metabolism, reducing its level and efficacy. Avoid concomitant use; if unavoidable, monitor IN…
Major (5)
- Mitotane + Certain Cyp3a Substrates— Mitotane is a strong CYP3A inducer that may decrease levels of CYP3A substrates, potentially leading to serious therapeu…
- Mitotane + Fostemsavir Tromethamine— Significantly decreases temsavir plasma concentrations, which may lead to loss of virologic response.
- Mitotane + Macimorelin Acetate— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Mitotane + Medroxyprogesterone Acetate— Strong CYP3A inducer may decrease medroxyprogesterone acetate concentrations and reduce contraceptive efficacy. Avoid co…
- Mitotane + Rydapt— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
Moderate (2)
- Mitotane + Levothyroxine Sodium— May increase serum thyroxine-binding globulin concentration, resulting in initial transient increase in FT4 followed by …
- Mitotane + Liothyronine Sodium— May increase serum thyroxine-binding globulin concentration, altering T3 serum transport. Closely monitor thyroid hormon…