Nitrofurantoin has 38 known drug interactions based on U.S. FDA drug labeling data. 32 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Articaine Hydrochloride And Epinephrine, Articaine Hydrochloride And Epinephrine Bitartrate, Benzocaine, Butamben, And Tetracaine Hydrochloride. Patients taking Nitrofurantoin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 38
- Major
- 32
- Moderate
- 6
Major (32)
- Nitrofurantoin + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
- Nitrofurantoin + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
- Nitrofurantoin + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this antibiotic oxidizing agent with local anesthetics.
- Nitrofurantoin + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with antibiotics.
- Nitrofurantoin + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitrofurantoin + Dapsone— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Nitrofurantoin + Dapsone Gel, 5%— Concomitant use may increase risk of developing methemoglobinemia. Monitor closely.
- Nitrofurantoin + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
- Nitrofurantoin + Folic Acid— Nitrofurantoin administration results in folate deficiency.
- Nitrofurantoin + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Nitrofurantoin + Lidocaine 5%— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
- Nitrofurantoin + Lidocaine And Capsaicin— Antibiotic that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
- Nitrofurantoin + Lidocaine And Prilocaine— Antibiotic; increased risk of methemoglobinemia when concurrently exposed.
- Nitrofurantoin + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Nitrofurantoin + Lidocaine Hydrochloride And Epinephrine Bitartrate— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
- Nitrofurantoin + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to antibiotics.
- Nitrofurantoin + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Nitrofurantoin + Lidocaine Patch 5%— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Nitrofurantoin + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Nitrofurantoin + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to antibiotics.
- Nitrofurantoin + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to antibiotics.
- Nitrofurantoin + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics.
- Nitrofurantoin + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Nitrofurantoin + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with nitrofurantoin (an antibiotic).
- Nitrofurantoin + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to nitrofurantoin.
- Nitrofurantoin + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Nitrofurantoin + Probenecid— Inhibits renal tubular secretion of nitrofurantoin, increasing serum levels and toxicity risk while decreasing urinary l…
- Nitrofurantoin + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to nitrofurantoin.
- Nitrofurantoin + Sulfinpyrazone— Inhibits renal tubular secretion of nitrofurantoin, increasing serum levels and toxicity risk while decreasing urinary l…
- Nitrofurantoin + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
- Nitrofurantoin + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Nitrofurantoin + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.
Moderate (6)
- Nitrofurantoin + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitrofurantoin + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Nitrofurantoin + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
- Nitrofurantoin + Lidocaine And Tetracaine— Antibiotic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Nitrofurantoin + Magnesium Trisilicate— Antacids containing magnesium trisilicate reduce both rate and extent of nitrofurantoin absorption. Monitor for lack of …
- Nitrofurantoin + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics with bupivacaine.