Increased risk of methemoglobinemia when concurrently exposed to articaine.
Source: NLP:articaine hydrochloride and epinephrine
Nitrofurantoin Interactions
Brand names: Nitrofurantoin
Nitrofuran Antibacterial
Route: Oral
Contraindications
CONTRAINDICATIONS: Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug. Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38 to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age. Nitrofurantoin Capsules, USP (monohydrate/ macrocrystals) is contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin. Nitrofurantoin Capsules, USP (monohydrate/ macrocrystals) is also contraindicated in those patients with known hypersensitivity to nitrofurantoin.
Pregnancy & Breastfeeding
Pregnancy Teratogenic effects: Pregnancy Category B. Several reproduction studies have been performed in rabbits and rats at doses up to six times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to nitrofurantoin. In a single published study conducted in mice at 68 times the human dose (based on mg/kg administered to the dam), growth retardation and a low incidence of minor and common malformations were observed. However, at 25 times the human dose, fetal malformations were not observed; the relevance of these findings to humans is uncertain. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Non-teratogenic effects: Nitrofurantoin has been shown in one published transplacental carcinogenicity study to induce lung papillary adenomas in the F1 generation mice at doses 19 times the human dose on a mg/kg basis. The relationship of this finding to potential human carcinogenesis is presently unknown. Because of the uncertainty regarding the human implications of these animal data, this drug should be used during pregnancy only if clearly needed.
29 interactions on record
Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
Source: NLP:articaine hydrochloride, epinephrine bitartrate
Increased risk of methemoglobinemia when concurrently exposed to this antibiotic oxidizing agent with local anesthetics.
Source: NLP:benzocaine, butamben, and tetracaine hydrochloride
Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
Source: NLP:bupivacaine hydrochloride
Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
Source: NLP:dapsone
Nitrofurantoin administration results in folate deficiency.
Source: NLP:folic acid
Increased risk of methemoglobinemia when used concurrently with lidocaine.
Source: NLP:lidocaine
Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Source: NLP:lidocaine 5%
Antibiotic that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
Source: NLP:lidocaine and capsaicin
Antibiotic; increased risk of methemoglobinemia when concurrently exposed.
Source: NLP:lidocaine and prilocaine
Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Source: NLP:lidocaine hydrochloride
Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Source: NLP:lidocaine hydrochloride and epinephrine bitartrate
Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to antibiotics.
Source: NLP:lidocaine hydrochloride and hydrocortisone acetate
Increased risk of methemoglobinemia when lidocaine is concurrently exposed to antibiotics.
Source: NLP:lidocaine and menthol
Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to antibiotics.
Source: NLP:lidothol patch
Increased risk of methemoglobinemia when concurrently exposed to antibiotics.
Source: NLP:marcaine, lidocaine, povidone iodine
Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
Source: NLP:mepivacaine hydrochloride
Increased risk of methemoglobinemia when penicillin is concurrently administered with nitrofurantoin (an antibiotic).
Source: NLP:penicillin g benzathine and penicillin g procaine
Increased risk of methemoglobinemia when prilocaine is concurrently exposed to nitrofurantoin.
Source: NLP:prilocaine hcl and epinephrine
Increased risk of methemoglobinemia when used concurrently with prilocaine.
Source: NLP:prilocaine hydrochloride
Inhibits renal tubular secretion of nitrofurantoin, increasing serum levels and toxicity risk while decreasing urinary levels and efficacy.
Source: NLP:nitrofurantoin
Increased risk of developing methemoglobinemia when concurrently exposed to nitrofurantoin.
Source: NLP:ropivacaine hydrochloride
Inhibits renal tubular secretion of nitrofurantoin, increasing serum levels and toxicity risk while decreasing urinary levels and efficacy.
Source: NLP:nitrofurantoin
Increased risk of methemoglobinemia when concurrently exposed.
Source: NLP:bupivacaine hydrochloride, lidocaine hydrochloride, triamcinolone acetonide, povidine iodine
Nitrofurantoin + BupivacaineModerate
May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
Source: NLP:bupivacaine
Increased risk of methemoglobinemia when concurrently exposed.
Source: NLP:bupivacaine hydrochloride and epinephrine bitartrate
Antibiotic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
Source: NLP:lidocaine and tetracaine
Antacids containing magnesium trisilicate reduce both rate and extent of nitrofurantoin absorption. Monitor for lack of efficacy.
Source: NLP:nitrofurantoin
Increased risk of methemoglobinemia when concurrently exposed to antibiotics with bupivacaine.
Source: NLP:methylprednisolone acetate, bupivacaine hydrochloride, povidone-iodine