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Perphenazine

Also known as: Perphenazine

Phenothiazine

Route: Oral

7 interactions on record⛔ Black Box Warning

Perphenazine has 7 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Desvenlafaxine, Desvenlafaxine Er, Desvenlafaxine Succinate. Patients taking Perphenazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 7
Moderate: 7

Moderate (7)

Perphenazine + Desvenlafaxine— Desvenlafaxine increases perphenazine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment ne…
Perphenazine + Desvenlafaxine Er— Desvenlafaxine increases perphenazine exposure. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment …
Perphenazine + Desvenlafaxine Succinate— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
Perphenazine + Fluoxetine— Fluoxetine inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose redu…
Perphenazine + Paroxetine— Paroxetine inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose redu…
Perphenazine + Paroxetine Hydrochloride— Increased exposure of CYP2D6 substrate; decrease dosage if needed.
Perphenazine + Sertraline— Sertraline inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose redu…

Perphenazine + Desvenlafaxine🟡Moderate

Desvenlafaxine increases perphenazine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment needed with 100 mg or lower.

Perphenazine + Desvenlafaxine Er🟡Moderate

Desvenlafaxine increases perphenazine exposure. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment needed with 100 mg or lower.

Perphenazine + Desvenlafaxine Succinate🟡Moderate

Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenlafaxine.

Perphenazine + Fluoxetine🟡Moderate

Fluoxetine inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose reduction may be necessary to avoid toxicity.

Perphenazine + Paroxetine🟡Moderate

Paroxetine inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose reduction may be necessary to avoid toxicity.

Perphenazine + Paroxetine Hydrochloride🟡Moderate

Increased exposure of CYP2D6 substrate; decrease dosage if needed.

Perphenazine + Sertraline🟡Moderate

Sertraline inhibits P450 2D6, increasing perphenazine plasma concentrations. Close monitoring is essential and dose reduction may be necessary to avoid toxicity.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.