Clomipramine Hydrochloride has 18 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Clonidine, Flecainide. Patients taking Clomipramine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Contraindicated
- 1
- Major
- 9
- Moderate
- 8
Contraindicated (1)
- Clomipramine Hydrochloride + Mao Inhibitors— Clomipramine should not be used with MAO inhibitors.
Major (9)
- Clomipramine Hydrochloride + Clonidine— Tricyclic antidepressants block the pharmacologic effects of clonidine; such an effect may be anticipated with clomipram…
- Clomipramine Hydrochloride + Flecainide— Type 1C antiarrhythmic that inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity.
- Clomipramine Hydrochloride + Fluoxetine— Inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity in normal metabolizers.
- Clomipramine Hydrochloride + Fluvoxamine— SSRI that inhibits P450 2D6 and P450 1A2, both involved in clomipramine metabolism, may increase plasma levels.
- Clomipramine Hydrochloride + Guanethidine— Tricyclic antidepressants block the pharmacologic effects of guanethidine; such an effect may be anticipated with clomip…
- Clomipramine Hydrochloride + Paroxetine— SSRI that inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity.
- Clomipramine Hydrochloride + Propafenone— Type 1C antiarrhythmic that inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity.
- Clomipramine Hydrochloride + Quinidine— Inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity.
- Clomipramine Hydrochloride + Sertraline— SSRI that inhibits P450 2D6 and may increase clomipramine plasma levels, potentially causing toxicity.
Moderate (8)
- Clomipramine Hydrochloride + Barbiturates— Barbiturates decrease plasma levels of clomipramine.
- Clomipramine Hydrochloride + Cimetidine— Cimetidine increases plasma levels of clomipramine through cytochrome P450 2D6 inhibition.
- Clomipramine Hydrochloride + Cns-Active Drugs— Caution is advised when using clomipramine concomitantly with other CNS-active drugs due to primary CNS effects of clomi…
- Clomipramine Hydrochloride + Haloperidol— Haloperidol increases plasma concentration of clomipramine.
- Clomipramine Hydrochloride + Methylphenidate— Methylphenidate increases plasma levels of tricyclic antidepressants including clomipramine.
- Clomipramine Hydrochloride + Phenobarbital— Clomipramine administration increases plasma levels of phenobarbital when given concomitantly.
- Clomipramine Hydrochloride + Phenothiazines— Substrates for P450 2D6 that inhibit the enzyme and may increase clomipramine plasma concentrations.
- Clomipramine Hydrochloride + Phenytoin— Phenytoin decreases plasma levels of clomipramine.