Cocaine Hydrochloride has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Phenylephrine Hci, Disulfiram. Patients taking Cocaine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Major
- 1
- Moderate
- 1
Contraindicated (2)
- Cocaine Hydrochloride + Epinephrine— Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal sur…
- Cocaine Hydrochloride + Phenylephrine Hci— Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal sur…
Major (1)
- Cocaine Hydrochloride + Disulfiram— Increases plasma cocaine exposure (AUC and Cmax) by several fold after intranasal or intravenous administration. Avoid u…
Moderate (1)
- Cocaine Hydrochloride + Echothiophate— Irreversible plasma cholinesterase inhibitor that may decrease plasma cholinesterase activity, potentially reducing coca…