Brand names: Goprelto
Route: Nasal
FDA Black Box Warning
WARNING: ABUSE AND DEPENDENCE CNS stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence [see Warning and Precautions (5.1) . ] WARNING: ABUSE AND DEPENDENCE See full prescribing information for complete boxed warning. CNS stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence. (5.1)
Contraindications
4 CONTRAINDICATIONS GOPRELTO is contraindicated in patients with a known history of hypersensitivity to cocaine hydrochloride, other ester-based anesthetics, or any other component of the product. Known hypersensitivity to cocaine hydrochloride, other ester-based anesthetics, or any other component of GOPRELTO. ( 4 )
4 interactions on record
Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal surgery. Avoid use of additional vasoconstrictor agents with cocaine hydrochloride nasal solution.
Source: NLP:cocaine hydrochloride
Reports of myocardial ischemia, myocardial infarction, and ventricular arrhythmias with concomitant use during nasal surgery. Avoid use of additional vasoconstrictor agents with cocaine hydrochloride nasal solution.
Source: NLP:cocaine hydrochloride
Increases plasma cocaine exposure (AUC and Cmax) by several fold after intranasal or intravenous administration. Avoid use of cocaine hydrochloride nasal solution in patients taking disulfiram.
Source: NLP:cocaine hydrochloride
Irreversible plasma cholinesterase inhibitor that may decrease plasma cholinesterase activity, potentially reducing cocaine clearance and increasing exposure. Monitor for adverse reactions.
Source: NLP:cocaine hydrochloride