Diethylpropion Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Anorectic Agents, Monoamine Oxidase Inhibitors (Maois), Other Anticholinergic Agents. Patients taking Diethylpropion Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 3
- Major
- 1
- Moderate
- 6
Contraindicated (3)
- Diethylpropion Hydrochloride + Anorectic Agents— Combined use with other anorectic agents is contraindicated due to potential for serious cardiac problems.
- Diethylpropion Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Hypertension may result when diethylpropion is used with MAO inhibitors due to monoamine interaction.
- Diethylpropion Hydrochloride + Other Anticholinergic Agents— Combined use may have potential for serious cardiac problems; efficacy has not been studied.
Major (1)
- Diethylpropion Hydrochloride + Topical Local Anesthetics— Concurrent use may result in arrhythmias.
Moderate (6)
- Diethylpropion Hydrochloride + A-Methyldopa— Diethylpropion may interfere with antihypertensive effects; pressor effects may be additive.
- Diethylpropion Hydrochloride + Carbidopa— Diethylpropion may interfere with antihypertensive effects; pressor effects may be additive.
- Diethylpropion Hydrochloride + Guanethidine— Pressor effects are additive; diethylpropion may interfere with antihypertensive efficacy.
- Diethylpropion Hydrochloride + Insulin Human— Antidiabetic drug requirements may be altered when used concurrently with diethylpropion.
- Diethylpropion Hydrochloride + Methyldopa— Diethylpropion may interfere with antihypertensive effects of α-methyldopa.
- Diethylpropion Hydrochloride + Phenothiazines— Concurrent use may antagonize the anorectic effect of diethylpropion.