Oxymorphone Hydrochloride has 18 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Linezolid, Methylene Blue, Monoamine Oxidase Inhibitors (Maois). Patients taking Oxymorphone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Contraindicated
- 3
- Major
- 15
Contraindicated (3)
- Oxymorphone Hydrochloride + Linezolid— MAOI-like interaction may result in serotonin syndrome or opioid toxicity.
- Oxymorphone Hydrochloride + Methylene Blue— MAOI-like interaction may result in serotonin syndrome or opioid toxicity.
- Oxymorphone Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Not recommended; may manifest as serotonin syndrome or opioid toxicity including respiratory depression and coma.
Major (15)
- Oxymorphone Hydrochloride + Alcohol— Concomitant use can increase oxymorphone plasma levels and result in potentially fatal overdose.
- Oxymorphone Hydrochloride + Anakinra— Concomitant use may result in serotonin syndrome.
- Oxymorphone Hydrochloride + Cyclobenzaprine— Serotonergic muscle relaxant that may result in serotonin syndrome when used concomitantly.
- Oxymorphone Hydrochloride + Gabapentin— CNS depressant with additive effect increasing risk of hypotension, respiratory depression, profound sedation, coma, and…
- Oxymorphone Hydrochloride + Metaxalone— Serotonergic muscle relaxant that may result in serotonin syndrome when used concomitantly.
- Oxymorphone Hydrochloride + Mirtazapine— Serotonergic drug that may result in serotonin syndrome when used concomitantly.
- Oxymorphone Hydrochloride + Mixed Agonist/Antagonist And Partial Agonist Opioid Analgesics— May reduce analgesic effect of oxymorphone or precipitate withdrawal symptoms.
- Oxymorphone Hydrochloride + Mixed Agonist/Antagonist Opioid Analgesics— May reduce analgesic effect of oxymorphone or precipitate withdrawal symptoms.
- Oxymorphone Hydrochloride + Nitrazepam— Additive CNS depressant effect increases risk of hypotension, respiratory depression, profound sedation, coma, and death…
- Oxymorphone Hydrochloride + Pregabalin— CNS depressant with additive effect increasing risk of hypotension, respiratory depression, profound sedation, coma, and…
- Oxymorphone Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use with serotonergic drugs has resulted in serotonin syndrome.
- Oxymorphone Hydrochloride + Tcas— Concomitant use can result in serotonin syndrome.
- Oxymorphone Hydrochloride + Tramadol— Serotonergic drug that may result in serotonin syndrome when used concomitantly.
- Oxymorphone Hydrochloride + Trazodone— Serotonergic drug that may result in serotonin syndrome when used concomitantly.
- Oxymorphone Hydrochloride + Triptans— Concomitant use with serotonergic drugs has resulted in serotonin syndrome.