Paliperidone Palmitate has 9 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Rifampin, St. John'S Wort. Patients taking Paliperidone Palmitate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 4
- Moderate
- 5
Major (4)
- Paliperidone Palmitate + Carbamazepine— Strong CYP3A4/P-gp inducer that may decrease paliperidone exposure. Avoid during 3-month dosing interval if possible; co…
- Paliperidone Palmitate + Rifampin— Strong CYP3A4/P-gp inducer that may decrease paliperidone exposure. Avoid during 3-month dosing interval if possible; co…
- Paliperidone Palmitate + St. John'S Wort— Strong CYP3A4/P-gp inducer that may decrease paliperidone exposure. Avoid during 3-month dosing interval if possible; co…
- Paliperidone Palmitate + Strong Cyp3a4 And P-Glycoprotein Inducers— Concomitant use may decrease paliperidone exposure. Avoid during dosing interval if possible; consider paliperidone exte…
Moderate (5)
- Paliperidone Palmitate + Alcohol— Concomitant use may modulate CNS effects of paliperidone palmitate. Use with caution.
- Paliperidone Palmitate + Centrally Acting Drugs— Concomitant use may modulate CNS effects of paliperidone palmitate. Use with caution.
- Paliperidone Palmitate + Dopamine Agonists— Paliperidone may antagonize the effects of dopamine agonists. Monitor and manage patient as clinically appropriate.
- Paliperidone Palmitate + Drugs With Potential For Inducing Orthostatic Hypotension— Additive effect may occur with paliperidone palmitate's potential for inducing orthostatic hypotension. Monitor orthosta…
- Paliperidone Palmitate + Levodopa— Paliperidone may antagonize the effect of levodopa. Monitor and manage patient as clinically appropriate.