May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
Propofol Interactions
Brand names: Propofol
General Anesthetic
Route: Intravenous
Contraindications
4 CONTRAINDICATIONS Propofol injectable emulsion is contraindicated in patients with a known hypersensitivity to propofol or any of propofol injectable emulsion components. Propofol injectable emulsion is contraindicated in patients with a history of anaphylaxis to eggs, egg products, soybeans or soy products. Known hypersensitivity to propofol, egg or soybean ( 4 )
Pregnancy & Breastfeeding
8.1 Pregnancy Risk Summary Data from randomized controlled trials, cohort studies and case series over several decades with propofol use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Most of the reported exposures to propofol describe propofol exposure at the time of cesarean delivery. There are reports of neonatal depression in infants exposed to propofol during delivery (see Clinical Considerations ) . In animal reproduction studies, decreased pup survival concurrent with increased maternal mortality was observed with intravenous administration of propofol to pregnant rats either prior to mating and during early gestation or during late gestation and early lactation at exposures less than the human induction dose of 2.5 mg/kg. In pregnant rats administered 15 mg/kg/day intravenous propofol (equivalent to the human induction dose) from two weeks prior to mating to early in gestation (Gestation Day 7), offspring that were allowed to mate had increased post implantation losses. The pharmacological activity (anesthesia) of the drug on the mother is probably responsible for the adverse effects seen in the offspring. Published studies in pregnant primates demonstrate that the administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity during the period of peak brain development increases neuronal apoptosis in the developing brain of the offspring when used for longer than 3 hours. There are no data on pregnancy exposures in primates corresponding to periods prior to the third trimester in humans [see Data , Warnings and Precautions (5.3) , and Use in Specific Populations (8.4) ] . The clinical significance of these nonclinical findings is not known, and the benefits of appropriate anesthesia in pregnant women who require procedures should be balanced with the potential risks suggested by the nonclinical data. The estimated background r
24 interactions on record
May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is routinely used.
Source: NLP:propofol
Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or propofol may be required.
Source: NLP:dexmedetomidine
May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
Propofol + EnfluraneMajor
Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is routinely used.
Source: NLP:propofol
Propofol + FentanylMajor
May increase anesthetic/sedative effects and cardiorespiratory depression. Concomitant use with propofol may result in serious bradycardia in pediatric patients.
Source: NLP:propofol
Propofol + HalothaneMajor
Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is routinely used.
Source: NLP:propofol
Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is routinely used.
Source: NLP:propofol
May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
CNS depressant that accentuates the sedative effect of midazolam, requiring dose adjustment.
Source: NLP:midazolam hydrochloride
Propofol + MorphineMajor
May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood pressure and cardiac output.
Source: NLP:propofol
Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is routinely used.
Source: NLP:propofol
Propofol + ValproateMajor
May lead to increased blood levels of propofol. Propofol dose should be reduced and patients monitored closely for increased sedation or cardiorespiratory depression.
Source: NLP:propofol
Co-administration with dexmedetomidine hydrochloride leads to enhancement of pharmacodynamic effects. Dosage reduction may be required.
Source: NLP:dexmedetomidine hydrochloride
Co-administration leads to enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or propofol may be required.
Source: NLP:dexmedetomidine hydrochloride in 0.9% sodium chloride
Propofol + Divalproex SodiumModerate
Dosage adjustment of propofol may be necessary when used concomitantly with divalproex sodium delayed-release tablets.
Source: NLP:divalproex sodium
Propofol + Ephedrine SulfateModerate
Augments pressor effect of ephedrine. Carefully monitor blood pressure.
Source: NLP:ephedrine sulfate
CYP3A4 inhibitor that may increase lidocaine plasma levels by reducing lidocaine clearance.
Source: NLP:lidocaine hydrochloride
Propofol + Nitrous OxideModerate
May increase anesthetic/sedative and cardiorespiratory effects; propofol dose may require adjustment during maintenance.
Source: NLP:propofol
Propofol + Valproate SodiumModerate
Dosage adjustment of propofol may be necessary if used concomitantly with valproate due to altered pharmacokinetics.
Source: NLP:valproate sodium
Propofol + Valproic AcidModerate
Dosage adjustment may be necessary if used concomitantly with valproic acid.
Source: NLP:valproic acid
No clinically significant change in onset, intensity, or duration of action observed.
Source: NLP:propofol