Propofol has 28 known drug interactions based on U.S. FDA drug labeling data. 18 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Barbiturates, Chloral Hydrate, Desflurane. Patients taking Propofol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Major
- 18
- Moderate
- 8
- Minor
- 2
Major (18)
- Propofol + Barbiturates— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Chloral Hydrate— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Desflurane— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Propofol + Dexmedetomidine— Concomitant use may cause enhanced CNS depressant effects. Dosage reduction of dexmedetomidine or propofol may be requir…
- Propofol + Dexmedetomidine Hydrochloride— Enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or propofol may be required. No pharmacok…
- Propofol + Droperidol— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Enflurane— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Propofol + Fentanyl— May increase anesthetic/sedative effects and cardiorespiratory depression. Concomitant use with propofol may result in s…
- Propofol + Halothane— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Propofol + Isoflurane— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Propofol + Magnesium Sulfate Heptahydrate— Potentiation and prolongation of analgesia and CNS depression is possible. Monitor depth of CNS depression frequently an…
- Propofol + Magnesium Sulfate In Dextrose— Potentiation and prolongation of analgesia and CNS depression is possible. Magnesium antagonizes NMDA receptors.
- Propofol + Meperidine— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Midazolam Hydrochloride— CNS depressant that accentuates the sedative effect of midazolam, requiring dose adjustment.
- Propofol + Morphine— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Nitrazepam— May increase anesthetic/sedative effects and cardiorespiratory depression; can result in pronounced decreases in blood p…
- Propofol + Sevoflurane— Increases anesthetic/sedative and cardiorespiratory effects of propofol during maintenance anesthesia. Concurrent use is…
- Propofol + Valproate— May lead to increased blood levels of propofol. Propofol dose should be reduced and patients monitored closely for incre…
Moderate (8)
- Propofol + Dexmedetomidine Hydrochloride In 0.9% Sodium Chloride— Co-administration leads to enhancement of pharmacodynamic effects. Reduction in dosage of dexmedetomidine or propofol ma…
- Propofol + Divalproex Sodium— Dosage adjustment of propofol may be necessary when used concomitantly with divalproex sodium delayed-release tablets.
- Propofol + Ephedrine Sulfate— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
- Propofol + Lidocaine Hydrochloride— CYP3A4 inhibitor that may increase lidocaine plasma levels by reducing lidocaine clearance.
- Propofol + Nitrous Oxide— May increase anesthetic/sedative and cardiorespiratory effects; propofol dose may require adjustment during maintenance.
- Propofol + Remimazolam Besylate— Sedative effect of remimazolam besylate can be accentuated by propofol. Dose titration required with continuous vital si…
- Propofol + Valproate Sodium— Dosage adjustment of propofol may be necessary if used concomitantly with valproate due to altered pharmacokinetics.
- Propofol + Valproic Acid— Dosage adjustment may be necessary if used concomitantly with valproic acid.
Minor (2)
- Propofol + Muscle Relaxants— Propofol does not cause clinically significant changes in onset, intensity, or duration of action.
- Propofol + Succinylcholine— No clinically significant change in onset, intensity, or duration of action observed.