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Imipramine Pamoate

Also known as: Imipramine Pamoate

Route: Oral

9 interactions on record⛔ Black Box Warning

Imipramine Pamoate has 9 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Barbiturates, Cimetidine, Flecainide. Patients taking Imipramine Pamoate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Moderate: 9

Moderate (9)

Imipramine Pamoate + Barbiturates— Hepatic enzyme inducers that decrease imipramine plasma concentrations. Dosage adjustment of imipramine may be necessary…
Imipramine Pamoate + Cimetidine— Inhibits P450 2D6 and hepatic enzymes, increasing imipramine plasma concentrations. May require dose adjustment and TCA …
Imipramine Pamoate + Flecainide— Type 1C antiarrhythmic that inhibits P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment …
Imipramine Pamoate + Fluoxetine— SSRI that inhibits P450 2D6 and hepatic enzymes, increasing imipramine plasma concentrations. At least 5 weeks may be ne…
Imipramine Pamoate + Paroxetine— SSRI that inhibits P450 2D6, increasing imipramine plasma concentrations. Caution and dose adjustment may be necessary d…
Imipramine Pamoate + Phenytoin— Hepatic enzyme inducer that decreases imipramine plasma concentrations. Dosage adjustment of imipramine may be necessary…
Imipramine Pamoate + Propafenone— Type 1C antiarrhythmic that inhibits P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment …
Imipramine Pamoate + Quinidine— Inhibits cytochrome P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment and TCA level mon…
Imipramine Pamoate + Sertraline— SSRI that inhibits P450 2D6, increasing imipramine plasma concentrations. Caution and dose adjustment may be necessary d…

Imipramine Pamoate + Barbiturates🟡Moderate

Hepatic enzyme inducers that decrease imipramine plasma concentrations. Dosage adjustment of imipramine may be necessary.

Imipramine Pamoate + Cimetidine🟡Moderate

Inhibits P450 2D6 and hepatic enzymes, increasing imipramine plasma concentrations. May require dose adjustment and TCA level monitoring.

Imipramine Pamoate + Flecainide🟡Moderate

Type 1C antiarrhythmic that inhibits P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment and TCA level monitoring.

Imipramine Pamoate + Fluoxetine🟡Moderate

SSRI that inhibits P450 2D6 and hepatic enzymes, increasing imipramine plasma concentrations. At least 5 weeks may be necessary before initiating imipramine after fluoxetine withdrawal due to long half-life.

Imipramine Pamoate + Paroxetine🟡Moderate

SSRI that inhibits P450 2D6, increasing imipramine plasma concentrations. Caution and dose adjustment may be necessary during co-administration or switching.

Imipramine Pamoate + Phenytoin🟡Moderate

Hepatic enzyme inducer that decreases imipramine plasma concentrations. Dosage adjustment of imipramine may be necessary.

Imipramine Pamoate + Propafenone🟡Moderate

Type 1C antiarrhythmic that inhibits P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment and TCA level monitoring.

Imipramine Pamoate + Quinidine🟡Moderate

Inhibits cytochrome P450 2D6, increasing imipramine plasma concentrations. May require dose adjustment and TCA level monitoring.

Imipramine Pamoate + Sertraline🟡Moderate

SSRI that inhibits P450 2D6, increasing imipramine plasma concentrations. Caution and dose adjustment may be necessary during co-administration or switching.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.