Ephedrine Sulfate has 15 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Digitalis Glycosides, Ergonovine, Methylergonovine. Patients taking Ephedrine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 4
- Moderate
- 11
Major (4)
- Ephedrine Sulfate + Digitalis Glycosides— May increase possibility of arrhythmias when given with ephedrine. Carefully monitor patients on cardiac glycosides.
- Ephedrine Sulfate + Ergonovine— Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor bloo…
- Ephedrine Sulfate + Methylergonovine— Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor bloo…
- Ephedrine Sulfate + Oxytocin— Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor bloo…
Moderate (11)
- Ephedrine Sulfate + Atropine— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Cardiac Glycosides— May increase possibility of arrhythmias. Carefully monitor patients receiving both drugs.
- Ephedrine Sulfate + Clonidine— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Guanethidine— Ephedrine may inhibit neuron blockage produced by guanethidine, resulting in loss of antihypertensive effectiveness. Mon…
- Ephedrine Sulfate + Mephentermine— Antagonizes pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Augments the pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Propofol— Augments pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Quinidine— Antagonizes pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Reserpine— Antagonizes pressor effect of ephedrine. Carefully monitor blood pressure.
- Ephedrine Sulfate + Rocuronium— Ephedrine may reduce the onset time of neuromuscular blockade when used simultaneously with anesthetic induction for int…
- Ephedrine Sulfate + Theophylline— Concomitant use may increase frequency of nausea, nervousness, and insomnia. Monitor patient and manage symptoms accordi…