Antacids Containing Calcium%2C Magnesium%2C Or Aluminum + Ofloxacin Interaction
Moderateinteraction on record
Description
Antacids form chelates with quinolones, substantially interfering with ofloxacin absorption and resulting in considerably lower systemic levels. Should not be taken within 2 hours before or after ofloxacin.
Mechanism
Chelate formation with metal cations
Source: NLP:ofloxacin