Omeprazole%2C Sodium Bicarbonate + Diazepam Interaction
Moderateinteraction on record
Description
CYP2C19 Substrates (e.g., clopidogrel, citalopram, cilostazol, phenytoin, diazepam) Clopidogrel Clinical Impact: Concomitant use of omeprazole 80 mg results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition [see Clinical Pharmacology (12.3) ]. Diazepam Clinical Impact: Increased exposure of diazepam [see Clinical Pharmacology (12.3) ] . Intervention: Monitor patients for increased sedation and reduce the dose of diazepam as needed.
Source: FDA drug label - omeprazole, sodium bicarbonate