Omeprazole And Sodium Bicarbonate has 30 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atazanavir, Clarithromycin, Nelfinavir. Patients taking Omeprazole And Sodium Bicarbonate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 30
- Contraindicated
- 4
- Major
- 4
- Moderate
- 16
Contraindicated (4)
- Omeprazole And Sodium Bicarbonate + Atazanavir— Concomitant use with omeprazole and sodium bicarbonate is contraindicated. Decreased exposure may reduce antiviral effec…
- Omeprazole And Sodium Bicarbonate + Clarithromycin— 7.4 Combination Therapy with Clarithromycin Concomitant administration of clarithromycin with other drugs can lead to se…
- Omeprazole And Sodium Bicarbonate + Nelfinavir— Concomitant use with omeprazole and sodium bicarbonate is contraindicated. Decreased exposure may reduce antiviral effec…
- Omeprazole And Sodium Bicarbonate + Rilpivirine— Concomitant use with omeprazole and sodium bicarbonate is contraindicated due to decreased exposure and reduced antivira…
Major (4)
- Omeprazole And Sodium Bicarbonate + Clopidogrel— Omeprazole 80 mg reduces plasma concentrations of clopidogrel's active metabolite and reduces platelet inhibition.
- Omeprazole And Sodium Bicarbonate + Methotrexate— Concomitant use may elevate and prolong serum concentrations of methotrexate and metabolite hydroxymethotrexate, possibl…
- Omeprazole And Sodium Bicarbonate + Saquinavir— Increased exposure of saquinavir when used concomitantly with omeprazole may increase toxicity; monitor for potential sa…
- Omeprazole And Sodium Bicarbonate + Warfarin— Increased INR and prothrombin time may lead to abnormal bleeding and death; monitor INR and prothrombin time and adjust …
Moderate (16)
- Omeprazole And Sodium Bicarbonate + Ampicillin Esters— Omeprazole and sodium bicarbonate may interfere with ampicillin ester bioavailability through effects on gastric pH.
- Omeprazole And Sodium Bicarbonate + Cilostazol— CYP2C19 substrate; concomitant use with omeprazole may increase exposure due to inhibition of CYP2C19.
- Omeprazole And Sodium Bicarbonate + Citalopram— CYP2C19 substrate; concomitant use with omeprazole may increase exposure due to inhibition of CYP2C19.
- Omeprazole And Sodium Bicarbonate + Cyclosporine— Omeprazole and sodium bicarbonate can prolong cyclosporine elimination. Monitor for possible dose adjustments.
- Omeprazole And Sodium Bicarbonate + Diazepam— CYP2C19 Substrates (e.g., clopidogrel, citalopram, cilostazol, phenytoin, diazepam) Clopidogrel Clinical Impact: Concomi…
- Omeprazole And Sodium Bicarbonate + Digoxin— Omeprazole and sodium bicarbonate increases bioavailability of digoxin by approximately 10%. Monitor patients for potent…
- Omeprazole And Sodium Bicarbonate + Disulfiram— Omeprazole and sodium bicarbonate can prolong disulfiram elimination. Monitor for possible dose adjustments.
- Omeprazole And Sodium Bicarbonate + Erlotinib— Omeprazole and sodium bicarbonate may reduce absorption of erlotinib by increasing gastric pH.
- Omeprazole And Sodium Bicarbonate + Iron Salts— Omeprazole and sodium bicarbonate may reduce absorption of iron salts by decreasing gastric acidity.
- Omeprazole And Sodium Bicarbonate + Ketoconazole— Omeprazole and sodium bicarbonate may reduce absorption of ketoconazole by decreasing gastric pH.
- Omeprazole And Sodium Bicarbonate + Mycophenolate Mofetil— Omeprazole and sodium bicarbonate reduces exposure to mycophenolic acid, the active metabolite of MMF, possibly due to d…
- Omeprazole And Sodium Bicarbonate + Nitrazepam— Omeprazole and sodium bicarbonate can prolong elimination of benzodiazepines. Monitor for possible dose adjustments.
- Omeprazole And Sodium Bicarbonate + Omeprazole— ( 7.1 ) • Drugs metabolized by cytochrome P450 (e.g., diazepam, warfarin, phenytoin, cyclosporine, disulfiram, benzodiaz…
- Omeprazole And Sodium Bicarbonate + Phenytoin— CYP2C19 substrate; concomitant use with omeprazole may increase exposure due to inhibition of CYP2C19.
- Omeprazole And Sodium Bicarbonate + Tacrolimus— Omeprazole and sodium bicarbonate may increase serum levels of tacrolimus. Monitor for potential dose adjustments.
- Omeprazole And Sodium Bicarbonate + Voriconazole— Voriconazole may increase plasma levels of omeprazole.