Relugolix%2C Estradiol Hemihydrate%2C And Norethindrone Acetate + P Gp Inhibitors (Oral) Interaction
Majorinteraction on record
Description
Co-administration increases AUC and Cmax of relugolix, may increase risk of adverse reactions. Avoid use; if unavoidable, separate dosing by at least 6 hours and monitor.
Mechanism
P-glycoprotein inhibition
Source: NLP:relugolix, estradiol hemihydrate, and norethindrone acetate