St. John'S Wort + Methadone Hydrochloride Interaction

Majorinteraction on record

Description

CYP3A4, CYP2B6, CYP2C19, and CYP2C9 inducer decreases methadone plasma concentration, resulting in decreased efficacy or withdrawal symptoms.

Mechanism

Induction of CYP-mediated methadone N-demethylation

Source: NLP:methadone hydrochloride

Related drug profiles

All St. John'S Wort interactions →All Methadone Hydrochloride interactions →
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