acitretin and methotrexate: what the product label says

The product label for acitretin names methotrexate in its drug-interaction information. The complete selected section is reproduced below so that qualifications stay with the finding.

Which products this evidence covers

Acitretin — CAPSULE — ORAL

Labeled active ingredients: ACITRETIN. Routes: ORAL. Dosage forms: CAPSULE.

Supporting label passage

Section: Methotrexate

An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate. Consequently, the combination of methotrexate with acitretin is also contraindicated (see CONTRAINDICATIONS ).

Read the full product label on DailyMed. Label version 16, dated 2023-12-20.

Limits of this evidence

This passage applies to the labeled product and circumstances it describes. It must not be generalized to other routes or formulations. It does not independently validate CDI’s severity category, establish safety for an individual, or replace the full label. The stored interaction description and classification have not been changed by this article.

How this brief was prepared

Automatic checks matched drug identities, retrieved and preserved the label, and checked the full quoted section with AI assistance on 2026-10-22. The public explanation uses a fixed template; model-written medical advice is not published. Independent clinical review has not been recorded.

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