adefovir dipivoxil and tenofovir disoproxil fumarate: what the product label says

The product label for tenofovir disoproxil fumarate names adefovir dipivoxil in its drug-interaction information. The complete selected section is reproduced below so that qualifications stay with the finding.

Which products this evidence covers

Tenofovir Disoproxil Fumarate — TABLET, FILM COATED — ORAL

Labeled active ingredients: TENOFOVIR DISOPROXIL FUMARATE; TENOFOVIR ANHYDROUS. Routes: ORAL. Dosage forms: TABLET, FILM COATED.

Supporting label passage

Section: 7.1 Drugs Affecting Renal Function

Tenofovir is primarily eliminated by the kidneys [see Clinical Pharmacology ( 12.3)]. Coadministration of tenofovir disoproxil fumarate tablets with drugs that are eliminated by active tubular secretion may increase concentrations of tenofovir and/or the coadministered drug. Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions ( 5.2)]. Drugs that decrease renal function may increase concentrations of tenofovir. In the treatment of chronic hepatitis B, tenofovir disoproxil fumarate tablets should not be administered in combination with HEPSERA (adefovir dipivoxil).

Read the full product label on DailyMed. Label version 1, dated 2024-08-05.

Limits of this evidence

This passage applies to the labeled product and circumstances it describes. It must not be generalized to other routes or formulations. It does not independently validate CDI’s severity category, establish safety for an individual, or replace the full label. The stored interaction description and classification have not been changed by this article.

How this brief was prepared

Automatic checks matched drug identities, retrieved and preserved the label, and checked the full quoted section with AI assistance on 2026-10-24. The public explanation uses a fixed template; model-written medical advice is not published. Independent clinical review has not been recorded.

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