alcohol and ramelteon: what the product label says

The product label for ramelteon names ethanol in its drug-interaction information. The complete selected section is reproduced below so that qualifications stay with the finding.

Which products this evidence covers

Ramelteon — TABLET, FILM COATED — ORAL

Labeled active ingredients: RAMELTEON. Routes: ORAL. Dosage forms: TABLET, FILM COATED.

Supporting label passage

Section: 7 DRUG INTERACTIONS

Rifampin (strong CYP enzyme inducer): Decreases exposure to and effects of ramelteon. ( 7.1) Ketoconazole (strong CYP3A4 inhibitor): Increases AUC for ramelteon; administer with caution. ( 7.1) Fluconazole (strong CYP2C9 inhibitor): Increases systemic exposure of ramelteon; administer with caution. ( 7.1) Donepezil: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with donepezil. ( 7.1) Doxepin: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with doxepin. ( 7.1) Alcohol: Causes additive psychomotor impairment; should not be used in combination. ( 7.2)

Read the full product label on DailyMed. Label version 2, dated 2024-12-31.

Limits of this evidence

This passage applies to the labeled product and circumstances it describes. It must not be generalized to other routes or formulations. It does not independently validate CDI’s severity category, establish safety for an individual, or replace the full label. The stored interaction description and classification have not been changed by this article.

How this brief was prepared

Automatic checks matched drug identities, retrieved and preserved the label, and checked the full quoted section with AI assistance on 2026-10-26. The public explanation uses a fixed template; model-written medical advice is not published. Independent clinical review has not been recorded.

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