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Azole Antifungals

Azole antifungals treat fungal infections. They are potent CYP3A4 inhibitors, making them one of the most interaction-prone drug classes — affecting statins, anticoagulants, immunosuppressants, and many others.

14 drugs in this class6 notable interactions shown

Azole Antifungals Drugs (14)

Clotrimazole TopicalClotrimazoleClotrimazole Topical Solution Usp, 1%Clotrimazole Topical Solution Usp, 1%CotrimoxazoleEfinaconazoleJubliaFluconazoleItraconazoleKetoconazoleLuliconazoleLuzuMiconazoleOteseconazoleVivjoaPosaconazolePosaconazole Delayed-ReleasePosaconazoleTerconazoleTerconazoleVoriconazole

Notable Azole Antifungals Interactions

Clotrimazole Topical + Amphotericin Bℹ️Unknown

Synergism or antagonism between clotrimazole and amphotericin B has not been reported.

Clotrimazole Topical + Cotrimoxazoleℹ️Unknown

Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C.

Clotrimazole Topical + Flucytosineℹ️Unknown

Synergism or antagonism between clotrimazole and flucytosine has not been reported.

Clotrimazole Topical Solution Usp, 1% + Cotrimoxazoleℹ️Unknown

Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C.

Clotrimazole Topical Solution Usp, 1% + Nystatinℹ️Unknown

Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C.

Cotrimoxazole + Methylergonovine⛔Contraindicated

Moderate CYP 3A4 inhibitor; should not be co-administered with methylergonovine.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.