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Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate

Also known as: Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate

Route: Sublingual

Check Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate Interactions →

15 interactions on record

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate has 15 known drug interactions based on U.S. FDA drug labeling data. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Gabapentin, Muscle Relaxants. Patients taking Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 15
Major: 9
Moderate: 4

Major (9)

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Alcohol— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Gabapentin— Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death when used conc…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Muscle Relaxants— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Nitrazepam— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Pregabalin— Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death when used conc…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Sedating Antihistamines— Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Sedatives— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Topical Local Anesthetics— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Tranquilizers— Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Moderate (4)

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Atazanavir— Other PIs with CYP3A4 inhibitory activity (atazanavir and atazanavir/ritonavir) resulted in elevated levels of buprenorp…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Erythromycin— CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects includ…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Ketoconazole— CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects includ…
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Ritonavir— CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects includ…

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Alcohol⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Gabapentin⚠️Major

Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Muscle Relaxants⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Nitrazepam⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Pregabalin⚠️Major

Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Sedating Antihistamines⚠️Major

Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Sedatives⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Topical Local Anesthetics⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Tranquilizers⚠️Major

Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Atazanavir🟡Moderate

Other PIs with CYP3A4 inhibitory activity (atazanavir and atazanavir/ritonavir) resulted in elevated levels of buprenorphine and norbuprenorphine, and patients in one study reported increased sedation. Symptoms of opioid excess have been found in post-marketing reports of patients receiving buprenorphine and atazanavir with and without ritonavir concomitantly. Intervention: Monitor patients taking Buprenorphine and Naloxone Sublingual Tablets and atazanavir with and without ritonavir, and reduce dose of Buprenorphine and Naloxone Sublingual Tablets if warranted.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Erythromycin🟡Moderate

CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Ketoconazole🟡Moderate

CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Ritonavir🟡Moderate

CYP3A4 inhibitor increases buprenorphine plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Lopinavirℹ️Unknown

Antiretrovirals: Protease inhibitors (PIs) Clinical Impact: Studies have shown some antiretroviral protease inhibitors (PIs) with CYP3A4 inhibitory activity (nelfinavir, lopinavir/ritonavir, ritonavir) have little effect on buprenorphine pharmacokinetic and no significant pharmacodynamic effects.

Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate + Nelfinavirℹ️Unknown

Antiretrovirals: Protease inhibitors (PIs) Clinical Impact: Studies have shown some antiretroviral protease inhibitors (PIs) with CYP3A4 inhibitory activity (nelfinavir, lopinavir/ritonavir, ritonavir) have little effect on buprenorphine pharmacokinetic and no significant pharmacodynamic effects.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.