Streptomycin has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rifampin, Ethacrynic Acid, Furosemide. Patients taking Streptomycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 7
- Moderate
- 3
Contraindicated (1)
- Streptomycin + Rifampin— j Concomitant use with rifampin in 2 children k Administered with rifampin (10 mg/kg daily) l Administered with an antib…
Major (7)
- Streptomycin + Ethacrynic Acid— Coadministration potentiates ototoxic effects of streptomycin.
- Streptomycin + Furosemide— Coadministration potentiates ototoxic effects of streptomycin.
- Streptomycin + Gentamicin Sulfate— Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.
- Streptomycin + Mannitol— Coadministration potentiates ototoxic effects of streptomycin.
- Streptomycin + Neostigmine Methylsulfate— Streptomycin has nondepolarizing neuromuscular blocking action; neostigmine dose adjustments may be required to reverse …
- Streptomycin + Pyridostigmine Bromide— Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.
- Streptomycin + Vecuronium Bromide— Streptomycin may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium…
Moderate (3)
- Streptomycin + Ascorbic Acid— Ascorbic acid may decrease the activity of streptomycin. Standard monitoring of antibiotic efficacy is warranted.
- Streptomycin + Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin— Thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid decrease the antibiotic activity of streptomycin.
- Streptomycin + Multiple Vitamins Injection— Thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid decrease streptomycin antibiotic activity.