Tacrine has 4 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fluvoxamine Maleate, Deferasirox, Fexinidazole. Patients taking Tacrine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 1
- Moderate
- 3
Major (1)
- Tacrine + Fluvoxamine Maleate— Coadministration increased tacrine Cmax and AUC five- and eight-fold, causing nausea, vomiting, sweating, and diarrhea.
Moderate (3)
- Tacrine + Deferasirox— Deferasirox inhibits CYP1A2 resulting in increased tacrine concentration. Monitor for exposure related toxicity.
- Tacrine + Fexinidazole— Fexinidazole inhibits CYP1A2, increasing tacrine concentrations and risk of adverse reactions.
- Tacrine + Theophylline— Inhibits theophylline metabolism, resulting in increased serum theophylline concentrations. May require dose reduction t…