Home›Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate

Also known as: Pradaxa

Route: Oral

Check Dabigatran Etexilate Mesylate Interactions →

8 interactions on record⛔ Black Box Warning

Dabigatran Etexilate Mesylate has 8 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rifampin, Dronedarone, Ketoconazole. Patients taking Dabigatran Etexilate Mesylate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 1
Moderate: 2
Minor: 5

Major (1)

Dabigatran Etexilate Mesylate + Rifampin— P-gp inducer that reduces exposure to dabigatran and should generally be avoided.

Moderate (2)

Dabigatran Etexilate Mesylate + Dronedarone— P-gp inhibitor requiring dosage reduction to 75 mg twice daily in patients with moderate renal impairment (CrCl 30-50 mL…
Dabigatran Etexilate Mesylate + Ketoconazole— In patients with moderate renal impairment (CrCl 30-50 mL/min), reduce the dosage of PRADAXA to 75 mg twice daily when a…

Minor (5)

Dabigatran Etexilate Mesylate + Amiodarone— P-gp inhibitor that does not require dosage adjustment of PRADAXA.
Dabigatran Etexilate Mesylate + Clarithromycin— P-gp inhibitor that does not require dosage adjustment of PRADAXA.
Dabigatran Etexilate Mesylate + Quinidine— P-gp inhibitor that does not require dosage adjustment of PRADAXA.
Dabigatran Etexilate Mesylate + Ticagrelor— P-gp inhibitor that does not require dosage adjustment of PRADAXA.
Dabigatran Etexilate Mesylate + Verapamil— P-gp inhibitor that does not require dosage adjustment of PRADAXA.

Dabigatran Etexilate Mesylate + Rifampin⚠️Major

P-gp inducer that reduces exposure to dabigatran and should generally be avoided.

Dabigatran Etexilate Mesylate + Dronedarone🟡Moderate

P-gp inhibitor requiring dosage reduction to 75 mg twice daily in patients with moderate renal impairment (CrCl 30-50 mL/min); avoid in severe renal impairment.

Dabigatran Etexilate Mesylate + Ketoconazole🟡Moderate

In patients with moderate renal impairment (CrCl 30-50 mL/min), reduce the dosage of PRADAXA to 75 mg twice daily when administered concomitantly with the P-gp inhibitors dronedarone or systemic ketoconazole. 7.3 Prophylaxis of Deep Vein Thrombosis and Pulmonary Embolism in Adult Patients Following Hip Replacement Surgery In patients with CrCl ≥ 50 mL/min who have concomitant administration of P-gp inhibitors such as dronedarone or systemic ketoconazole, it may be helpful to separate the timing of administration of PRADAXA and the P-gp inhibitor by several hours.

Dabigatran Etexilate Mesylate + Amiodarone🟢Minor