Lurasidone Hydrochloride has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 9 are contraindicated combinations that should be avoided entirely. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Clarithromycin, Ketoconazole. Patients taking Lurasidone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 9
- Major
- 10
Contraindicated (9)
- Lurasidone Hydrochloride + Carbamazepine— Strong CYP3A4 inducer that decreases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Clarithromycin— Strong CYP3A4 inhibitor that increases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Ketoconazole— Strong CYP3A4 inhibitor that increases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Mibefradil— Strong CYP3A4 inhibitor that increases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Phenytoin— Strong CYP3A4 inducer that decreases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Rifampin— Strong CYP3A4 inducer that decreases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Ritonavir— Strong CYP3A4 inhibitor that increases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + St. John'S Wort— Strong CYP3A4 inducer that decreases lurasidone exposure; concomitant use is contraindicated.
- Lurasidone Hydrochloride + Voriconazole— Strong CYP3A4 inhibitor that increases lurasidone exposure; concomitant use is contraindicated.
Major (10)
- Lurasidone Hydrochloride + Atazanavir— Moderate CYP3A4 inhibitor increases lurasidone exposure. Lurasidone dose should be reduced to half the original level.
- Lurasidone Hydrochloride + Bosentan— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Lurasidone Hydrochloride + Diltiazem— Moderate CYP3A4 inhibitor increases lurasidone exposure. Lurasidone dose should be reduced to half the original level.
- Lurasidone Hydrochloride + Efavirenz— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Lurasidone Hydrochloride + Erythromycin— Moderate CYP3A4 inhibitor increases lurasidone exposure. Lurasidone dose should be reduced to half the original level.
- Lurasidone Hydrochloride + Etravirine— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Lurasidone Hydrochloride + Fluconazole— Moderate CYP3A4 inhibitor increases lurasidone exposure. Lurasidone dose should be reduced to half the original level.
- Lurasidone Hydrochloride + Modafinil— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Lurasidone Hydrochloride + Nafcillin— Moderate CYP3A4 inducer decreases lurasidone exposure. Lurasidone dose should be increased.
- Lurasidone Hydrochloride + Verapamil— Moderate CYP3A4 inhibitor increases lurasidone exposure. Lurasidone dose should be reduced to half the original level.