Apomorphine has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Apomorphine Hydrochloride, Metoclopramide, Metoclopramide Hydrochloride. Patients taking Apomorphine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 5
- Major
- 1
- Moderate
- 1
Contraindicated (5)
- Apomorphine + Apomorphine Hydrochloride— 7 DRUG INTERACTIONS Concomitant use of antihypertensive medications and vasodilators: increased risk for hypotension, my…
- Apomorphine + Metoclopramide— Dopaminergic agonist with opposing effects on dopamine. Avoid concomitant use due to decreased therapeutic effect and po…
- Apomorphine + Metoclopramide Hydrochloride— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of parkinsonian symptoms. Avoid concomita…
- Apomorphine + Ondansetron— 7.2 Apomorphine Based on reports of profound hypotension and loss of consciousness when apomorphine was administered wit…
- Apomorphine + Ondansetron Hydrochloride— 7.2 Apomorphine Based on reports of profound hypotension and loss of consciousness when apomorphine was administered wit…
Major (1)
- Apomorphine + Carbidopa, Levodopa And Entacapone— May result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure. Metabolized by COMT.
Moderate (1)
- Apomorphine + Tolcapone— Tolcapone may influence pharmacokinetics of COMT substrates like apomorphine. Dose reduction should be considered when c…