Colestipol Hydrochloride has 16 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Chlorothiazide, Digitoxin, Digoxin. Patients taking Colestipol Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Major
- 8
- Moderate
- 5
Major (8)
- Colestipol Hydrochloride + Chlorothiazide— Absorption of chlorothiazide is markedly decreased even when administered one hour before colestipol hydrochloride.
- Colestipol Hydrochloride + Digitoxin— Colestipol may reduce availability of digitoxin with conflicting study results. Particular caution required; discontinui…
- Colestipol Hydrochloride + Digoxin— Colestipol may reduce availability of digoxin with conflicting study results. Particular caution required; discontinuing…
- Colestipol Hydrochloride + Furosemide— Absorption of furosemide is significantly decreased when given simultaneously with colestipol hydrochloride.
- Colestipol Hydrochloride + Gemfibrozil— Absorption of gemfibrozil is significantly decreased when given simultaneously with colestipol hydrochloride.
- Colestipol Hydrochloride + Hydrochlorothiazide— Absorption of hydrochlorothiazide is significantly decreased when given simultaneously with colestipol hydrochloride.
- Colestipol Hydrochloride + Penicillin G— Absorption of penicillin G is significantly decreased when given simultaneously with colestipol hydrochloride.
- Colestipol Hydrochloride + Tetracycline— Absorption of tetracycline is significantly decreased when given simultaneously with colestipol hydrochloride.
Moderate (5)
- Colestipol Hydrochloride + Hydrocortisone— Bile acid binding resins may interfere with the absorption of hydrocortisone.
- Colestipol Hydrochloride + Mycophenilic Acid— Colestipol may reduce mycophenolic acid exposure and potentially reduce efficacy of mycophenolate mofetil by binding bil…
- Colestipol Hydrochloride + Mycophenolate Mofetil— Colestipol may reduce mycophenolic acid exposure and potentially reduce efficacy of mycophenolate mofetil by binding bil…
- Colestipol Hydrochloride + Phosphate-Binding Agents— Bile acid binding resins may interfere with the absorption of oral phosphate supplements.
- Colestipol Hydrochloride + Propranolol— Colestipol may delay propranolol absorption and increase time to reach maximum concentration by approximately 30 minutes…