Urinary Antiseptic Antispasmodic has 8 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Ketoconazole, Opioid Analgesics. Patients taking Urinary Antiseptic Antispasmodic should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 3
- Moderate
- 5
Major (3)
- Urinary Antiseptic Antispasmodic + Acetazolamide— These drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria.
- Urinary Antiseptic Antispasmodic + Ketoconazole— Drug Interactions because of this product's effect on gastrointestinal motility and gastric emptying, it may decrease th…
- Urinary Antiseptic Antispasmodic + Opioid Analgesics— May result in increased risk of severe constipation due to reduced intestinal motility.
Moderate (5)
- Urinary Antiseptic Antispasmodic + Andthiazide— May cause urine to become alkaline, reducing the effectiveness of methenamine by inhibiting its conversion to formaldehy…
- Urinary Antiseptic Antispasmodic + Antacids Containing Calcium— May reduce absorption of hyoscyamine and cause urine to become alkaline, reducing methenamine effectiveness. Space doses…
- Urinary Antiseptic Antispasmodic + Antiperistaltic Antidiarrheal Drugs— May reduce absorption of hyoscyamine due to effects on gastrointestinal motility. Space doses 1 hour apart.
- Urinary Antiseptic Antispasmodic + Monoamine Oxidase Inhibitors (Maois)— Concurrent use may intensify antimuscarinic side effects.
- Urinary Antiseptic Antispasmodic + Urinary Alkalinizing Agents— May reduce effectiveness of methenamine by inhibiting its conversion to formaldehyde, causing urine to become alkaline.