Thioguanine has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Busulfan, Mercaptopurine, Mesalamine. Patients taking Thioguanine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Major
- 2
- Moderate
- 3
Major (2)
- Thioguanine + Busulfan— Additive myelosuppression and hepatotoxicity risk; portal hypertension and esophageal varices observed with long-term co…
- Thioguanine + Mercaptopurine— Complete cross-resistance between mercaptopurine and thioguanine; concurrent use not recommended.
Moderate (3)
- Thioguanine + Mesalamine— Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.
- Thioguanine + Olsalazine— Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.
- Thioguanine + Sulfasalazine— Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.