Thiopental has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Vecuronium Bromide, Probenecid, Midazolam. Patients taking Thiopental should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 1
- Major
- 1
- Moderate
- 5
Contraindicated (1)
- Thiopental + Vecuronium Bromide— Reconstituted vecuronium should not be mixed with thiopental in the same syringe or administered simultaneously through …
Major (1)
- Thiopental + Probenecid— Patients receiving probenecid require significantly less thiopental for anesthesia induction; anesthesia is significantl…
Moderate (5)
- Thiopental + Midazolam— Moderate reduction in induction dosage requirements of thiopental (about 15%).
- Thiopental + Midazolam Hydrochloride— Moderate reduction in induction dosage requirements of thiopental (about 15%) when used with midazolam.
- Thiopental + Midazolam In 0.8% Sodium Chloride— Moderate reduction in induction dosage requirements of thiopental (about 15%) when used concomitantly with midazolam.
- Thiopental + Probenecid And Colchicine— Patients receiving probenecid require significantly less thiopental for anesthesia induction, and anesthesia is signific…
- Thiopental + Salsalate— Salicylate competes with thiopental for protein binding sites, potentially affecting drug levels.