Tranquilizers has 34 known drug interactions based on U.S. FDA drug labeling data. 20 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Buprenorphine, Buprenorphine And Naloxone, Buprenorphine Hydrochloride. Patients taking Tranquilizers should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 34
- Major
- 20
- Moderate
- 13
Major (20)
- Tranquilizers + Buprenorphine— CNS depressants that increase risk of respiratory depression, profound sedation, coma, and death with concomitant bupren…
- Tranquilizers + Buprenorphine And Naloxone— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Tranquilizers + Buprenorphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Tranquilizers + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate— Increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.
- Tranquilizers + Butorphanol Tartrate— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Tranquilizers + Carbinoxamine Maleate— Tranquilizers cause additive CNS depressant effects with carbinoxamine. Avoid concomitant use.
- Tranquilizers + Doxylamine Succinate And Pyridoxine Hydrochloride— Concurrent use is not recommended; severe drowsiness can occur with CNS depressants.
- Tranquilizers + Doxylamine Succinate And Pyridoxine Hydrochloride, Delayed Release Tablets 10 Mg/10 Mg— Concurrent use of tranquilizers with doxylamine succinate and pyridoxine hydrochloride is not recommended due to severe …
- Tranquilizers + Hydrocodone Bitartrate And Acetaminophen— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death; reserve for patients where…
- Tranquilizers + Levorphanol Tartrate— Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.
- Tranquilizers + Methadone Hydrochloride— CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.
- Tranquilizers + Nalbuphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Tranquilizers + Oxycodone Hydrochloride— Additive CNS depression with potential respiratory depression, hypotension, profound sedation, or coma. Dose reduction r…
- Tranquilizers + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additiv…
- Tranquilizers + Pentobarbital Sodium— Concomitant use may produce additive CNS depressant effects.
- Tranquilizers + Phenobarbital— Additive depressant effects with phenobarbital; toxic effects and fatalities have occurred with this combination.
- Tranquilizers + Phenobarbital Sodium— Concomitant use of tranquilizers with barbiturates may produce additive central nervous system depressant effects.
- Tranquilizers + Promethazine Hydrochloride— Promethazine may increase, prolong, or intensify the sedative action; avoid or use reduced dosage.
- Tranquilizers + Promethazine Hydrochloride And Dextromethorphan Hydrobromide— Promethazine may increase, prolong, or intensify sedative action of tranquilizers.
- Tranquilizers + Remifentanil Hydrochloride— CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.
Moderate (13)
- Tranquilizers + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Additive CNS depressant effects when combined with dihydrocodeine; dose reduction of one or both agents recommended.
- Tranquilizers + Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide— Antihistamine component has additive CNS depressant effects with tranquilizers.
- Tranquilizers + Brompheniramine Maleate, Pseudoephedrine Hydrochloride,— Antihistamines have additive effects with tranquilizers and other CNS depressants.
- Tranquilizers + Brompheniramine, Pseudoephedrine, Dextromethorphan— Antihistamines have additive effects with tranquilizers and other CNS depressants.
- Tranquilizers + Clemastine Fumarate— Additive CNS depression may occur when antihistamines are administered concomitantly with tranquilizers.
- Tranquilizers + Cyproheptadine Hydrochloride— Tranquilizers may have additive CNS depressant effects with cyproheptadine.
- Tranquilizers + Dantrolene Sodium— Concomitant administration may result in further drowsiness due to CNS depressant effects.
- Tranquilizers + Difenoxin And Atropine Sulfate— MOTOFEN may potentiate the action of tranquilizers; patient should be closely monitored.
- Tranquilizers + Diphenhydramine Hydrochloride— Additive CNS depressant effects with diphenhydramine hydrochloride.
- Tranquilizers + Droperidol— Additive or potentiating CNS depressant effects; droperidol dose should be reduced when used concomitantly.
- Tranquilizers + Metoclopramide— Additive sedative effects can occur when metoclopramide is given with tranquilizers.
- Tranquilizers + Metoclopramide Hydrochloride— Additive sedative effects can occur when metoclopramide is given with tranquilizers.
- Tranquilizers + Promethazine Hydrochloride And Phenylephrine Hydrochloride— Promethazine may increase, prolong, or intensify sedative action; agents should be avoided or administered in reduced do…